tert-butyl 4-((4-(4-(methylsulfinyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((4-(4-(methylsulfinyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate
CAS No.:1401098-30-3
Molecular Formula:C₂₄H₃₅NO₄S
Molecular Weight:433.612
Hs Code.:

Synonyms:tert-butyl 4-((4-(4-(methylsulfinyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((4-(4-(methylsulfinyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-((4-(4-(methylsulfinyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

There total 6 articles about tert-butyl 4-((4-(4-(methylsulfinyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.3%

: 166386-48-7
(4-(methylsulfinyl)phenyl)boronic acid

: 1401098-20-1
tert-butyl 4-((4-(trifluoromethylsulfonyloxy)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

: 1401098-30-3
tert-butyl 4-((4-(4-(methylsulfinyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 1h; Inert atmosphere; Sealed tube; Microwave irradiation;

Reference yield:

: 198627-85-9
tert-butyl 4-((4-oxocyclohexyloxy)methyl)piperidine-1-carboxylate

: 1401098-30-3
tert-butyl 4-((4-(4-(methylsulfinyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 2.5 h / -78 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With sodium carbonate; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 103-16-2
4-Benzyloxyphenol

: 1401098-30-3
tert-butyl 4-((4-(4-(methylsulfinyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 72 h / 20 - 55 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 15 h / 23 °C / 760.05 Torr

3.1: hydrogen; sodium hydroxide / rhodium contaminated with carbon / water / 21 h / 60 - 70 °C / 7500.75 - 9750.98 Torr

3.2: 18 h / 23 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: 2.5 h / -78 - 20 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With di-isopropyl azodicarboxylate; hydrogen; sodium carbonate; triphenylphosphine; sodium hydroxide; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; rhodium contaminated with carbon; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;