tert-butyl 4-((4-(trifluoromethylsulfonyloxy)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((4-(trifluoromethylsulfonyloxy)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate
CAS No.:1401098-20-1
Molecular Formula:C₁₈H₂₈F₃NO₆S
Molecular Weight:443.485
Hs Code.:

Synonyms:tert-butyl 4-((4-(trifluoromethylsulfonyloxy)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((4-(trifluoromethylsulfonyloxy)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-((4-(trifluoromethylsulfonyloxy)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-((4-(trifluoromethylsulfonyloxy)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 198627-85-9
tert-butyl 4-((4-oxocyclohexyloxy)methyl)piperidine-1-carboxylate

: 1401098-20-1
tert-butyl 4-((4-(trifluoromethylsulfonyloxy)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

Guidance literature:: tert-butyl 4-((4-oxocyclohexyloxy)methyl)piperidine-1-carboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

N,N-phenylbistrifluoromethane-sulfonimide; In tetrahydrofuran; at -78 - 20 ℃; for 2.5h;

Reference yield:

: 103-16-2
4-Benzyloxyphenol

: 1401098-20-1
tert-butyl 4-((4-(trifluoromethylsulfonyloxy)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 72 h / 20 - 55 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 15 h / 23 °C / 760.05 Torr

3.1: hydrogen; sodium hydroxide / rhodium contaminated with carbon / water / 21 h / 60 - 70 °C / 7500.75 - 9750.98 Torr

3.2: 18 h / 23 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: 2.5 h / -78 - 20 °C

With di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; sodium hydroxide; lithium hexamethyldisilazane; palladium 10% on activated carbon; rhodium contaminated with carbon; In tetrahydrofuran; ethanol; water;

Reference yield:

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 1401098-20-1
tert-butyl 4-((4-(trifluoromethylsulfonyloxy)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 72 h / 20 - 55 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 15 h / 23 °C / 760.05 Torr

3.1: hydrogen; sodium hydroxide / rhodium contaminated with carbon / water / 21 h / 60 - 70 °C / 7500.75 - 9750.98 Torr

3.2: 18 h / 23 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: 2.5 h / -78 - 20 °C

With di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; sodium hydroxide; lithium hexamethyldisilazane; palladium 10% on activated carbon; rhodium contaminated with carbon; In tetrahydrofuran; ethanol; water;