2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methoxy-7-methyl-7,9-dihydro-8H-purin-8-one

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Chemical Name:2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methoxy-7-methyl-7,9-dihydro-8H-purin-8-one
CAS No.:1361569-86-9
Molecular Formula:C₂₀H₁₆FN₇O₂
Molecular Weight:405.391
Hs Code.:

Synonyms:2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methoxy-7-methyl-7,9-dihydro-8H-purin-8-one

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Chemical Property of 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methoxy-7-methyl-7,9-dihydro-8H-purin-8-one

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Technology Process of 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methoxy-7-methyl-7,9-dihydro-8H-purin-8-one

There total 3 articles about 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methoxy-7-methyl-7,9-dihydro-8H-purin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 67-56-1
methanol

: 1361569-82-5
2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-iodo-7-methyl-7,9-dihydro-8H-purin-8-one

: 1361569-86-9
2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methoxy-7-methyl-7,9-dihydro-8H-purin-8-one

Guidance literature:: With copper(l) iodide; 3,4,7,8-Tetramethyl-o-phenanthrolin; caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 8h; Microwave irradiation; Inert atmosphere; Sonication;

Reference yield:

: 1361569-18-7
6-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7-methyl-7,9-dihydro-8H-purin-8-one

: 1361569-86-9
2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methoxy-7-methyl-7,9-dihydro-8H-purin-8-one

Guidance literature:: Multi-step reaction with 2 steps

1: isopentyl nitrite; diiodomethane / 16 h / 85 °C

2: 3,4,7,8-Tetramethyl-o-phenanthrolin; caesium carbonate; copper(l) iodide / 1-methyl-pyrrolidin-2-one / 8 h / 80 °C / Microwave irradiation; Inert atmosphere; Sonication

With copper(l) iodide; diiodomethane; 3,4,7,8-Tetramethyl-o-phenanthrolin; caesium carbonate; isopentyl nitrite; In 1-methyl-pyrrolidin-2-one;

Reference yield:

: 625115-55-1
Riociguat

: 1361569-86-9
2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methoxy-7-methyl-7,9-dihydro-8H-purin-8-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 19 h / 0 - 20 °C

2: isopentyl nitrite; diiodomethane / 16 h / 85 °C

3: 3,4,7,8-Tetramethyl-o-phenanthrolin; caesium carbonate; copper(l) iodide / 1-methyl-pyrrolidin-2-one / 8 h / 80 °C / Microwave irradiation; Inert atmosphere; Sonication

With copper(l) iodide; diiodomethane; 3,4,7,8-Tetramethyl-o-phenanthrolin; sodium hexamethyldisilazane; caesium carbonate; isopentyl nitrite; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;