C₃₃H₃₁N₃O₆

Base Information

• Chemical Name: C₃₃H₃₁N₃O₆
• CAS No.: 134485-36-2
• Molecular Formula: C₃₃H₃₁N₃O₆
• Molecular Weight: 565.626
• Mol file: 134485-36-2.mol

Synonyms:C₃₃H₃₁N₃O₆

Chemical Property of C₃₃H₃₁N₃O₆

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₃₃H₃₁N₃O₆

There total 7 articles about C₃₃H₃₁N₃O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(2S,3S)-3-Azido-5,5-bis-benzyloxy-pentane-1,2-diol (134485-33-9) + benzoyl chloride (98-88-4) → C33H31N3O6 (134485-36-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane;

DOI:10.1021/ja00013a088

Reference yield:

3,3-dibenzyloxypropanal (134485-38-4) → C33H31N3O6 (134485-36-2)

Guidance literature:

Multi-step reaction with 5 steps

1: NaH / tetrahydrofuran

2: diisobutylaluminum hydride (DIBAL-H) / diethyl ether / -78 °C

3: 91 percent / tBuOOH, Ti(OiPr)4, (-)-diethyl tartrate ((-)-DET), 4-A sieves / CH₂Cl₂ / -20 °C

4: Ti(OiPr)4, Me₃SiN₃ / benzene

5: 91 percent / NEt₃, 4-dimethylaminopyridine (DMAP) / CH₂Cl₂

With titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; trimethylsilylazide; 4 A molecular sieve; sodium hydride; diisobutylaluminium hydride; (-)-diethyl tartrate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;

DOI:10.1021/ja00013a088

Reference yield:

5,5-Dibenzyloxy-2E-penten-1-ol (134485-31-7) → C33H31N3O6 (134485-36-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / tBuOOH, Ti(OiPr)4, (-)-diethyl tartrate ((-)-DET), 4-A sieves / CH₂Cl₂ / -20 °C

2: Ti(OiPr)4, Me₃SiN₃ / benzene

3: 91 percent / NEt₃, 4-dimethylaminopyridine (DMAP) / CH₂Cl₂

With titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; trimethylsilylazide; 4 A molecular sieve; (-)-diethyl tartrate; triethylamine; In dichloromethane; benzene;

DOI:10.1021/ja00013a088

upstream raw materials:

(2S,3S)-3-Azido-5,5-bis-benzyloxy-pentane-1,2-diol

benzoyl chloride

5,5-Dibenzyloxy-2E-penten-1-ol

3,3-dibenzyloxypropanal

Downstream raw materials:

3'-azido-2',3'-deoxythymidine