tert-butyl 2,2',2'',2'''-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-phenylene)bis(azanetriyl)tetraacetate

Base Information

• Chemical Name: tert-butyl 2,2',2'',2'''-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-phenylene)bis(azanetriyl)tetraacetate
• CAS No.: 1610690-90-8
• Molecular Formula: C₃₆H₅₉BN₂O₁₀
• Molecular Weight: 690.683
• Mol file: 1610690-90-8.mol

Synonyms:tert-butyl 2,2',2'',2'''-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-phenylene)bis(azanetriyl)tetraacetate

Chemical Property of tert-butyl 2,2',2'',2'''-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-phenylene)bis(azanetriyl)tetraacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2,2',2'',2'''-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-phenylene)bis(azanetriyl)tetraacetate

There total 5 articles about tert-butyl 2,2',2'',2'''-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-phenylene)bis(azanetriyl)tetraacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-butyl 2,2',2'',2'''-(4-bromo-1,2-phenylene)bis(azanetriyl)tetraacetate (1610690-87-3) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → tert-butyl 2,2',2'',2'''-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-phenylene)bis(azanetriyl)tetraacetate (1610690-90-8)

Guidance literature:

With palladium diacetate; triethylamine; CyJohnPhos; In 1,4-dioxane; at 90 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/ja502406x

Reference yield:

tert-butyl 2,2',2'',2'''-(4-bromo-1,2-phenylene)bis(azanetriyl)tetraacetate (1610690-87-3) + bis(pinacol)diborane (73183-34-3) → tert-butyl 2,2',2'',2'''-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-phenylene)bis(azanetriyl)tetraacetate (1610690-90-8)

Guidance literature:

With Pd₂(dba)3*HCl; potassium acetate; XPhos; In 1,4-dioxane; at 95 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/ja502406x

Reference yield:

C30H48N2O8 (1610690-86-2) → tert-butyl 2,2',2'',2'''-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-phenylene)bis(azanetriyl)tetraacetate (1610690-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium bromide; Oxone / methanol / 4 h / 20 °C

2: XPhos; potassium acetate; Pd₂(dba)3*HCl / 1,4-dioxane / 1.5 h / 95 °C / Inert atmosphere

With Oxone; Pd₂(dba)3*HCl; potassium acetate; potassium bromide; XPhos; In 1,4-dioxane; methanol;

DOI:10.1021/ja502406x

upstream raw materials:

bromoacetic acid tert-butyl ester

1,2-diamino-benzene

tert-butyl 2,2',2'',2'''-(4-bromo-1,2-phenylene)bis(azanetriyl)tetraacetate

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane