2,6-Bis-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-benzoic acid tert-butyl ester

Base Information

• Chemical Name: 2,6-Bis-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-benzoic acid tert-butyl ester
• CAS No.: 131326-41-5
• Molecular Formula: C₃₁H₅₈O₈Si₂
• Molecular Weight: 614.968
• Mol file: 131326-41-5.mol

Synonyms:2,6-Bis-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-benzoic acid tert-butyl ester

Chemical Property of 2,6-Bis-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-benzoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-Bis-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-benzoic acid tert-butyl ester

There total 4 articles about 2,6-Bis-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-Dihydroxybenzoic acid (303-07-1) → 2,6-Bis-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-benzoic acid tert-butyl ester (131326-41-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / benzene / 0.17 h / 80 °C

2: 1. Cs₂CO₃ / 1. DMF, 30min, 2. DMF, r.t., 10h

With caesium carbonate; In benzene;

DOI:10.1016/S0040-4020(01)87908-4

Reference yield:

2-[2-[[(1,1-dimethylethyl)-dimethylsilyl]oxy]ethoxy]ethanol (131326-39-1) → 2,6-Bis-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-benzoic acid tert-butyl ester (131326-41-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / pyridine / 4-dimethylaminopyridine (DMAP) / 3 h / 0 °C

2: 1. Cs₂CO₃ / 1. DMF, 30min, 2. DMF, r.t., 10h

With pyridine; caesium carbonate; dmap;

DOI:10.1016/S0040-4020(01)87908-4

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 2,6-Bis-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-benzoic acid tert-butyl ester (131326-41-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1. NaH / 1. THF, r.t., 90min, 2. r.t., 90min

2: 79 percent / pyridine / 4-dimethylaminopyridine (DMAP) / 3 h / 0 °C

3: 1. Cs₂CO₃ / 1. DMF, 30min, 2. DMF, r.t., 10h

With pyridine; sodium hydride; caesium carbonate; dmap;

DOI:10.1016/S0040-4020(01)87908-4

upstream raw materials:

tert-butyl 2,6-dihydroxybenzoate

Toluene-4-sulfonic acid 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-ethyl ester

2,6-Dihydroxybenzoic acid

2-[2-[[(1,1-dimethylethyl)-dimethylsilyl]oxy]ethoxy]ethanol

Downstream raw materials:

2,6-Bis-[2-(2-hydroxy-ethoxy)-ethoxy]-benzoic acid tert-butyl ester

2-{2-[2-(2-Benzyloxycarbonylamino-acetylsulfanyl)-ethoxy]-ethoxy}-6-{2-[2-((S)-2-tert-butoxycarbonylamino-propionylsulfanyl)-ethoxy]-ethoxy}-benzoic acid tert-butyl ester

2-{2-[2-(2-Benzyloxycarbonylamino-acetylsulfanyl)-ethoxy]-ethoxy}-6-[2-(2-mercapto-ethoxy)-ethoxy]-benzoic acid tert-butyl ester

2,6-Bis-[2-(2-acetylsulfanyl-ethoxy)-ethoxy]-benzoic acid tert-butyl ester