4-[2-[[4-[[4-(carboxymethyl)isoquinolin-1-yl]methyl]benzoyl]amino]ethyl]benzoic acid

Base Information

Chemical Name:4-[2-[[4-[[4-(carboxymethyl)isoquinolin-1-yl]methyl]benzoyl]amino]ethyl]benzoic acid
CAS No.:1233248-47-9
Molecular Formula:C₂₈H₂₄N₂O₅
Molecular Weight:468.509
Hs Code.:

Synonyms:4-[2-[[4-[[4-(carboxymethyl)isoquinolin-1-yl]methyl]benzoyl]amino]ethyl]benzoic acid

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Chemical Property of 4-[2-[[4-[[4-(carboxymethyl)isoquinolin-1-yl]methyl]benzoyl]amino]ethyl]benzoic acid

Chemical Property:

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Technology Process of 4-[2-[[4-[[4-(carboxymethyl)isoquinolin-1-yl]methyl]benzoyl]amino]ethyl]benzoic acid

There total 11 articles about 4-[2-[[4-[[4-(carboxymethyl)isoquinolin-1-yl]methyl]benzoyl]amino]ethyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1660146-47-3
C₂₉H₂₆N₂O₅

: 1233248-47-9
4-[2-[[4-[[4-(carboxymethyl)isoquinolin-1-yl]methyl]benzoyl]amino]ethyl]benzoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;
DOI:10.1248/cpb.c13-00980

Reference yield:

: 108052-76-2
4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester

: 1233248-47-9
4-[2-[[4-[[4-(carboxymethyl)isoquinolin-1-yl]methyl]benzoyl]amino]ethyl]benzoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene / 1.17 h / 60 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 2.25 h / -30 - 50 °C

2.2: 2 h / 60 °C

3.1: sodium hydroxide / tetrahydrofuran / 2.5 h / 50 °C

4.1: N,N-dimethyl-formamide; oxalyl dichloride / chloroform / 1.17 h / 0 °C

5.1: tetrahydrofuran; acetonitrile; dichloromethane / 3 h / 0 °C

6.1: silver(I) acetate / 1,4-dioxane; water / 0.75 h / 60 °C

7.1: dichloromethane; methanol / 0.33 h

8.1: trifluoroacetic acid / chloroform / 3.5 h / 0 - 20 °C

9.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / chloroform / 20 °C

10.1: sodium hydroxide / tetrahydrofuran / 2.5 h / 0 - 20 °C

With oxalyl dichloride; silver(I) acetate; sodium hexamethyldisilazane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; toluene; acetonitrile; 6.1: |Wolff Rearrangement;
DOI:10.1248/cpb.c13-00980

Reference yield:

: 1233249-89-2
tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide

: 1233248-47-9
4-[2-[[4-[[4-(carboxymethyl)isoquinolin-1-yl]methyl]benzoyl]amino]ethyl]benzoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 2.25 h / -30 - 50 °C

1.2: 2 h / 60 °C

2.1: sodium hydroxide / tetrahydrofuran / 2.5 h / 50 °C

3.1: N,N-dimethyl-formamide; oxalyl dichloride / chloroform / 1.17 h / 0 °C

4.1: tetrahydrofuran; acetonitrile; dichloromethane / 3 h / 0 °C

5.1: silver(I) acetate / 1,4-dioxane; water / 0.75 h / 60 °C

6.1: dichloromethane; methanol / 0.33 h

7.1: trifluoroacetic acid / chloroform / 3.5 h / 0 - 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / chloroform / 20 °C

9.1: sodium hydroxide / tetrahydrofuran / 2.5 h / 0 - 20 °C

With oxalyl dichloride; silver(I) acetate; sodium hexamethyldisilazane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; acetonitrile; 5.1: |Wolff Rearrangement;
DOI:10.1248/cpb.c13-00980