FLUPHENAZINE N-MUSTARD DIHYDROCHLORIDE

Base Information

• Chemical Name: FLUPHENAZINE N-MUSTARD DIHYDROCHLORIDE
• CAS No.: 83016-35-7
• Molecular Formula: C₂₂H₂₅ClF₃N₃S
• Molecular Weight: 455.975
• Mol file: 83016-35-7.mol

Synonyms:FluphenazineN-mustard; Fluphenazine mustard

Chemical Property of FLUPHENAZINE N-MUSTARD DIHYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 2.8E-12mmHg at 25°C
• Boiling Point: 553.2°C at 760 mmHg
• Flash Point: 288.3°C
• PSA: 35.02000
• Density: 1.274g/cm³
• LogP: 7.09940

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FLUPHENAZINE N-MUSTARD DIHYDROCHLORIDE

There total 7 articles about FLUPHENAZINE N-MUSTARD DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fluphenazine (69-23-8) → fluphenazine-N-mustard (83016-35-7)

Guidance literature:

With hydrogenchloride; thionyl chloride; In chloroform; for 3h; Heating;

Reference yield:

2-(trifluoromethyl)-10H-phenothiazine (92-30-8) → fluphenazine-N-mustard (83016-35-7)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) nBuLi, (ii) /BRN= 1114944/

2: NaI / butan-2-one / 20 h / Heating

3: HCl, SOCl₂ / CHCl₃ / 3 h / Heating

With hydrogenchloride; thionyl chloride; sodium iodide; In chloroform; butanone;

DOI:10.1002/jps.2600670209

Reference yield:

1-(2-hydroxyethyl)piperazine (103-76-4) → fluphenazine-N-mustard (83016-35-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaI / butan-2-one / 20 h / Heating

2: HCl, SOCl₂ / CHCl₃ / 3 h / Heating

With hydrogenchloride; thionyl chloride; sodium iodide; In chloroform; butanone;

DOI:10.1002/jps.2600670209

upstream raw materials:

Fluphenazine

1-(2-hydroxyethyl)piperazine

2-(trifluoromethyl)-10H-phenothiazine

10-(3-chloropropyl)-2-trifluoromethylphenothiazine

Refernces

• 1、 Hirata,Peng,Driscoll. "Potential CNS antitumor agents - Phenothiazines. II: Fluphenazine analogs". . p. 157 - 162. Retrieved 2007/10/04.