6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

Base Information

Chemical Name:6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one
CAS No.:1452230-84-0
Molecular Formula:C₂₅H₂₄Cl₂N₆O₂
Molecular Weight:511.411
Hs Code.:

Synonyms:6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

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Chemical Property of 6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

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Technology Process of 6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

There total 5 articles about 6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16153-81-4
4-(4-Methyl-piperazino)-anilin

: 1452230-82-8
6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one

: 1452230-84-0
6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: 6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 0.416667h;

4-(4-Methyl-piperazino)-anilin; In dichloromethane; at 45 ℃; for 24h;

Reference yield:

: 98276-75-6
4-methyl-2-(methylthio)pyrimidine-5-carboxylic acid

: 1452230-84-0
6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / 1,4-dioxane / 1 h / 20 °C

1.2: 100 °C

2.1: N,N-dimethyl-formamide / 24 h / 20 °C

3.1: cerium(III) chloride heptahydrate; sodium tetrahydroborate / dichloromethane; methanol / 0.17 h / 0 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.42 h / 20 °C

4.2: 24 h / 45 °C

With sodium tetrahydroborate; thionyl chloride; cerium(III) chloride heptahydrate; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1452230-52-2
N-(2,6-dichlorophenyl)-4-methyl-2-(methylthio)pyrimidine-5-carboxamide

: 1452230-84-0
6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 24 h / 20 °C

2.1: cerium(III) chloride heptahydrate; sodium tetrahydroborate / dichloromethane; methanol / 0.17 h / 0 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.42 h / 20 °C

3.2: 24 h / 45 °C

With sodium tetrahydroborate; cerium(III) chloride heptahydrate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;