1-(3,5-di-O-benzyl-2-O-methanesulfonyl-3-C-(methanesulfonyl-oxy)methyl-β-D-ribofuranosyl)thymine

Base Information

• Chemical Name: 1-(3,5-di-O-benzyl-2-O-methanesulfonyl-3-C-(methanesulfonyl-oxy)methyl-β-D-ribofuranosyl)thymine
• CAS No.: 754978-62-6
• Molecular Formula: C₂₇H₃₂N₂O₁₁S₂
• Molecular Weight: 624.69

Synonyms:1-(3,5-di-O-benzyl-2-O-methanesulfonyl-3-C-(methanesulfonyl-oxy)methyl-β-D-ribofuranosyl)thymine

Chemical Property of 1-(3,5-di-O-benzyl-2-O-methanesulfonyl-3-C-(methanesulfonyl-oxy)methyl-β-D-ribofuranosyl)thymine

Chemical Property:

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Technology Process of 1-(3,5-di-O-benzyl-2-O-methanesulfonyl-3-C-(methanesulfonyl-oxy)methyl-β-D-ribofuranosyl)thymine

There total 1 articles about 1-(3,5-di-O-benzyl-2-O-methanesulfonyl-3-C-(methanesulfonyl-oxy)methyl-β-D-ribofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(2-O-acetyl-3-C-(benzoyloxy)methyl-3,5-di-O-benzyl-β-D-ribofuranosyl)thymine (754978-61-5) + methanesulfonyl chloride (124-63-0) → 1-(3,5-di-O-benzyl-2-O-methanesulfonyl-3-C-(methanesulfonyl-oxy)methyl-β-D-ribofuranosyl)thymine (754978-62-6)

Guidance literature:

1-(2-O-acetyl-3-C-(benzoyloxy)methyl-3,5-di-O-benzyl-β-D-ribofuranosyl)thymine; With sodium methylate; In methanol; at 20 ℃;

methanesulfonyl chloride; With pyridine; at 0 - 20 ℃; for 3h;

DOI:10.1021/jo0491861

Reference yield:

1-(3,5-di-O-benzyl-2-O-methanesulfonyl-3-C-(methanesulfonyl-oxy)methyl-β-D-ribofuranosyl)thymine (754978-62-6) → (1R,2R,4R,5S)-1-benzyloxy-2-(benzyloxy)methyl-4-(thymin-1-yl)-3,6-dioxabicyclo[3.2.0]heptane (207607-26-9)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 2h; Heating;

DOI:10.1021/jo0491861

upstream raw materials:

1-(2-O-acetyl-3-C-(benzoyloxy)methyl-3,5-di-O-benzyl-β-D-ribofuranosyl)thymine

methanesulfonyl chloride

Downstream raw materials:

(1R,2R,4R,5S)-1-benzyloxy-2-(benzyloxy)methyl-4-(thymin-1-yl)-3,6-dioxabicyclo[3.2.0]heptane

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