3-methyl-4-[6-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]indan-5-yloxymethyl]benzoic acid

Base Information

Chemical Name:3-methyl-4-[6-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]indan-5-yloxymethyl]benzoic acid
CAS No.:459841-58-8
Molecular Formula:C₂₇H₃₁NO₆S
Molecular Weight:497.612
Hs Code.:

Synonyms:3-methyl-4-[6-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]indan-5-yloxymethyl]benzoic acid

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Chemical Property of 3-methyl-4-[6-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]indan-5-yloxymethyl]benzoic acid

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Technology Process of 3-methyl-4-[6-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]indan-5-yloxymethyl]benzoic acid

There total 11 articles about 3-methyl-4-[6-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]indan-5-yloxymethyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 916913-98-9
methyl 4-{[(6-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)oxy]methyl}-3-methylbenzoate

: 459841-58-8
3-methyl-4-[6-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]indan-5-yloxymethyl]benzoic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; methanol; at 20 ℃; for 1.5h;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 459841-58-8
3-methyl-4-[6-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]indan-5-yloxymethyl]benzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 47 percent / lithium aluminum hydride / tetrahydrofuran / 0.17 h / 20 °C

2: 61 percent / triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

3: 95 percent / PBr₃ / various solvent(s) / 0.5 h / -6 °C

4: 98 percent / potassium carbonate / dimethylformamide / 4 h / 50 °C

5: 96 percent / acetic acid; iron / H₂O / 1 h

6: 64 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

7: 86 percent / dimethylamine; Cs₂CO₃ / 80 °C

8: 83 percent / NaOH / methanol; dioxane / 1.5 h / 20 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; sodium hydroxide; lithium aluminium tetrahydride; phosphorus tribromide; iron; potassium carbonate; caesium carbonate; acetic acid; dimethyl amine; triethylamine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 17100-58-2
4-bromo-2-methylbenzyl alcohol

: 459841-58-8
3-methyl-4-[6-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]indan-5-yloxymethyl]benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 61 percent / triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

2: 95 percent / PBr₃ / various solvent(s) / 0.5 h / -6 °C

3: 98 percent / potassium carbonate / dimethylformamide / 4 h / 50 °C

4: 96 percent / acetic acid; iron / H₂O / 1 h

5: 64 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

6: 86 percent / dimethylamine; Cs₂CO₃ / 80 °C

7: 83 percent / NaOH / methanol; dioxane / 1.5 h / 20 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; sodium hydroxide; phosphorus tribromide; iron; potassium carbonate; caesium carbonate; acetic acid; dimethyl amine; triethylamine; palladium diacetate; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.001