methyl 3-methyl-4-{[(6-nitro-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

Base Information

Chemical Name:methyl 3-methyl-4-{[(6-nitro-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate
CAS No.:916913-80-9
Molecular Formula:C₁₉H₁₉NO₅
Molecular Weight:341.364
Hs Code.:

Synonyms:methyl 3-methyl-4-{[(6-nitro-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 3-methyl-4-{[(6-nitro-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

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Technology Process of methyl 3-methyl-4-{[(6-nitro-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

There total 5 articles about methyl 3-methyl-4-{[(6-nitro-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 82472-57-9
6-nitro-2,3-dihydro-1H-inden-5-ol

: 104447-92-9
4-bromomethyl-3-methylbenzoic acid methyl ester

: 916913-80-9
methyl 3-methyl-4-{[(6-nitro-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 4h;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 916913-80-9
methyl 3-methyl-4-{[(6-nitro-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 47 percent / lithium aluminum hydride / tetrahydrofuran / 0.17 h / 20 °C

2: 61 percent / triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

3: 95 percent / PBr₃ / various solvent(s) / 0.5 h / -6 °C

4: 98 percent / potassium carbonate / dimethylformamide / 4 h / 50 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; lithium aluminium tetrahydride; phosphorus tribromide; potassium carbonate; triethylamine; palladium diacetate; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 17100-58-2
4-bromo-2-methylbenzyl alcohol

: 916913-80-9
methyl 3-methyl-4-{[(6-nitro-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

2: 95 percent / PBr₃ / various solvent(s) / 0.5 h / -6 °C

3: 98 percent / potassium carbonate / dimethylformamide / 4 h / 50 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; phosphorus tribromide; potassium carbonate; triethylamine; palladium diacetate; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.001