methyl 3-methyl-4-{[(6-amino-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

Base Information

Chemical Name:methyl 3-methyl-4-{[(6-amino-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate
CAS No.:916913-84-3
Molecular Formula:C₁₉H₂₁NO₃
Molecular Weight:311.381
Hs Code.:

Synonyms:methyl 3-methyl-4-{[(6-amino-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

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Chemical Property of methyl 3-methyl-4-{[(6-amino-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

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Technology Process of methyl 3-methyl-4-{[(6-amino-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

There total 7 articles about methyl 3-methyl-4-{[(6-amino-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 916913-80-9
methyl 3-methyl-4-{[(6-nitro-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

: 916913-84-3
methyl 3-methyl-4-{[(6-amino-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

Guidance literature:: With iron; acetic acid; In water; for 1h;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 916913-84-3
methyl 3-methyl-4-{[(6-amino-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 47 percent / lithium aluminum hydride / tetrahydrofuran / 0.17 h / 20 °C

2: 61 percent / triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

3: 95 percent / PBr₃ / various solvent(s) / 0.5 h / -6 °C

4: 98 percent / potassium carbonate / dimethylformamide / 4 h / 50 °C

5: 96 percent / acetic acid; iron / H₂O / 1 h

With 1,1'-bis-(diphenylphosphino)ferrocene; lithium aluminium tetrahydride; phosphorus tribromide; iron; potassium carbonate; acetic acid; triethylamine; palladium diacetate; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 17100-58-2
4-bromo-2-methylbenzyl alcohol

: 916913-84-3
methyl 3-methyl-4-{[(6-amino-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

2: 95 percent / PBr₃ / various solvent(s) / 0.5 h / -6 °C

3: 98 percent / potassium carbonate / dimethylformamide / 4 h / 50 °C

4: 96 percent / acetic acid; iron / H₂O / 1 h

With 1,1'-bis-(diphenylphosphino)ferrocene; phosphorus tribromide; iron; potassium carbonate; acetic acid; triethylamine; palladium diacetate; In water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.001