1-[(5S)-2-methyl-5-(methylethyl)cyclohex-1-enyloxy]-1,1-dimethyl-1-silaethane

Base Information

• Chemical Name: 1-[(5S)-2-methyl-5-(methylethyl)cyclohex-1-enyloxy]-1,1-dimethyl-1-silaethane
• CAS No.: 1309660-00-1
• Molecular Formula: C₁₃H₂₆OSi
• Molecular Weight: 226.434
• Mol file: 1309660-00-1.mol

Synonyms:1-[(5S)-2-methyl-5-(methylethyl)cyclohex-1-enyloxy]-1,1-dimethyl-1-silaethane

Chemical Property of 1-[(5S)-2-methyl-5-(methylethyl)cyclohex-1-enyloxy]-1,1-dimethyl-1-silaethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(5S)-2-methyl-5-(methylethyl)cyclohex-1-enyloxy]-1,1-dimethyl-1-silaethane

There total 3 articles about 1-[(5S)-2-methyl-5-(methylethyl)cyclohex-1-enyloxy]-1,1-dimethyl-1-silaethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

chloro-trimethyl-silane (75-77-4) + (5S)-2-methyl-5-(methylethyl)cyclohexan-1-one (160168-89-8) → 1-[(5S)-2-methyl-5-(methylethyl)cyclohex-1-enyloxy]-1,1-dimethyl-1-silaethane (1309660-00-1)

Guidance literature:

With triethylamine; sodium iodide; In acetonitrile; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tet.2011.04.007

Reference yield:

(S)-p-mentha-6,8-dien-2-one (2244-16-8,6485-40-1) → 1-[(5S)-2-methyl-5-(methylethyl)cyclohex-1-enyloxy]-1,1-dimethyl-1-silaethane (1309660-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Rh/Al₂O₃; hydrogen / ethanol / 3.5 h / 20 °C / 31503.2 Torr / Autoclave

2: triethylamine; sodium iodide / acetonitrile / 4 h / 20 °C / Inert atmosphere

With Rh/Al₂O₃; hydrogen; triethylamine; sodium iodide; In ethanol; acetonitrile;

DOI:10.1016/j.tet.2011.04.007

Reference yield:

(5S)-2-methyl-5-(prop-1-en-2-yl)cyclohexan-1-one (201012-68-2) → 1-[(5S)-2-methyl-5-(methylethyl)cyclohex-1-enyloxy]-1,1-dimethyl-1-silaethane (1309660-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 48 h / 20 °C

1.2: 0.33 h / 0 °C

2.1: triethylamine; sodium iodide / acetonitrile / 4 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; sodium iodide; In ethyl acetate; acetonitrile; 1.2: Jones oxidation;

DOI:10.1016/j.tet.2011.04.007

upstream raw materials:

chloro-trimethyl-silane

(5S)-2-methyl-5-(methylethyl)cyclohexan-1-one

(S)-p-mentha-6,8-dien-2-one

(5S)-2-methyl-5-(prop-1-en-2-yl)cyclohexan-1-one

Downstream raw materials:

(2S,5S)-2-methyl-5-(methylethyl)-2-prop-2-enylcyclohexan-1-one

(2R,5S)-2-methyl-5-(methylethyl)-2-prop-2-enylcyclohexan-1-one