(2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid

Base Information

• Chemical Name: (2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid
• CAS No.: 38489-76-8
• Molecular Formula: C₁₀H₈O₄
• Molecular Weight: 192.171
• Mol file: 38489-76-8.mol

Synonyms:2-Propenoic acid, 3-(1,3-benzodioxol-5-yl)-, (E)-;

Chemical Property of (2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid

Chemical Property:

• Melting Point: 238 °C(Solv: acetic acid (64-19-7))
• Boiling Point: 361.5 °C at 760 mmHg
• PKA: 4.37±0.10(Predicted)
• Flash Point: 148.9 °C
• PSA: 55.76000
• Density: 1.41 g/cm³
• LogP: 1.51310
• Solubility.: Dimethyl Sulfoxide

Purity/Quality:

98%min ^*data from raw suppliers

(2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid

There total 40 articles about (2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl (2E)-3-(1,3-benzodioxol-5-yl)acrylate (40918-96-5) → 3,4-methylenedioxy-trans-cinnamic acid (2373-80-0,38489-76-8)

Guidance literature:

methyl (2E)-3-(1,3-benzodioxol-5-yl)acrylate; With water; sodium hydroxide; In tetrahydrofuran;

With hydrogenchloride; In water; pH=< 3;

DOI:10.3390/molecules14093833

Reference yield: 98.0%

piperonal (120-57-0,30024-74-9) + malonic acid (141-82-2) → 3,4-methylenedioxy-trans-cinnamic acid (2373-80-0,38489-76-8)

Guidance literature:

With aluminum oxide; lithium chloride; for 0.1h; microwave irradiation;

DOI:10.1081/SCC-120027254

Reference yield: 98.0%

piperonal (120-57-0,30024-74-9) + acetic acid (64-19-7,77671-22-8) → 3,4-methylenedioxy-trans-cinnamic acid (2373-80-0,38489-76-8)

Guidance literature:

piperonal; acetic acid; With titanium tetrachloride; In dichloromethane; at 25 ℃; for 0.333333h; Inert atmosphere;

With triethylamine; In dichloromethane; at 25 ℃; stereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.04.098

upstream raw materials:

piperonal

malonic acid

acetic anhydride

diethoxyphosphoryl-acetic acid ethyl ester

Downstream raw materials:

methyl 3-(3,4-dioxymethylenephenyl)propenoate

methyl (2E)-3-(1,3-benzodioxol-5-yl)acrylate

(E)-3-(benzo[d][1,3]dioxol-5-yl)prop-2-en-1-ol

(E)-3-(benzo[d][1,3]dioxol-5-yl)allyl 3-(3,4,5-trimethoxyphenyl)propiolate

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