(2R,3S)-N₁-((S)-1-((methylthio)methyl)-2-oxo-5-phenyl-2,3-dihydro1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

Base Information

• Chemical Name: (2R,3S)-N₁-((S)-1-((methylthio)methyl)-2-oxo-5-phenyl-2,3-dihydro1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide
• CAS No.: 1581704-54-2
• Molecular Formula: C₂₇H₂₈F₆N₄O₃S
• Molecular Weight: 602.601

Synonyms:(2R,3S)-N₁-((S)-1-((methylthio)methyl)-2-oxo-5-phenyl-2,3-dihydro1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

Chemical Property of (2R,3S)-N₁-((S)-1-((methylthio)methyl)-2-oxo-5-phenyl-2,3-dihydro1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of (2R,3S)-N₁-((S)-1-((methylthio)methyl)-2-oxo-5-phenyl-2,3-dihydro1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

There total 1 articles about (2R,3S)-N₁-((S)-1-((methylthio)methyl)-2-oxo-5-phenyl-2,3-dihydro1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-methylsulfanyl-methane (2373-51-5) + (2R,3S)-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide (1401066-80-5) → (2R,3S)-N1-((S)-1-((methylthio)methyl)-2-oxo-5-phenyl-2,3-dihydro1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide (1581704-54-2)

Guidance literature:

(2R,3S)-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide; With caesium carbonate; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

chloro-methylsulfanyl-methane; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

Reference yield: 84.0%

(2R,3S)-N1-((S)-1-((methylthio)methyl)-2-oxo-5-phenyl-2,3-dihydro1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide (1581704-54-2) + 3-(2-((bis(benzyloxy)phosphoryl)oxy)-4,6-dimethylphenyl)-3-methylbutanoic acid (153910-62-4) → ((S)-3-((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl3-(2-((bis(benzyloxy)phosphoryl)oxy)-4,6-dimethylphenyl)-3-methylbutanoate (1581704-58-6)

Guidance literature:

(2R,3S)-N₁-((S)-1-((methylthio)methyl)-2-oxo-5-phenyl-2,3-dihydro1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide; With sulfuryl dichloride; N,N-diethylethanamine hydrochloride; In dichloromethane; at 0 - 20 ℃; for 1h;

3-(2-((bis(benzyloxy)phosphoryl)oxy)-4,6-dimethylphenyl)-3-methylbutanoic acid; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

(2R,3S)-N1-((S)-1-((methylthio)methyl)-2-oxo-5-phenyl-2,3-dihydro1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide (1581704-54-2) → (2R,3S)-N1-((S)-1-(chloromethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide (1581704-55-3)

Guidance literature:

(2R,3S)-N₁-((S)-1-((methylthio)methyl)-2-oxo-5-phenyl-2,3-dihydro1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide; With N,N-diethylethanamine hydrochloride; In dichloromethane; at 20 ℃; for 0.0833333h;

With sulfuryl dichloride; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

upstream raw materials:

chloro-methylsulfanyl-methane

(2R,3S)-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

Downstream raw materials:

(2R,3S)-N₁-((S)-1-(chloromethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

((S)-3-((2R,3S)-3-Carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl2-(4-((di-tert-butoxyphosphoryl)oxy)phenyl)acetate

((3S)-3-(((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoyl)amino)2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

((3S)-3-(((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoyl)amino)2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl4-((phosphonooxy)methyl)benzoate

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