(+/-)-5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Base Information

Chemical Name:(+/-)-5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
CAS No.:82775-57-3
Molecular Formula:C₃₃H₃₅NO₅*ClH
Molecular Weight:562.106
Hs Code.:

Synonyms:(+/-)-5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Suppliers and Price of (+/-)-5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of (+/-)-5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

There total 6 articles about (+/-)-5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82775-54-0
(R)-5,7-dibenzyloxy-N-formyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

: 82775-57-3
(+/-)-5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 10percent aq. NaOH, 2.) 10percent ethanolic HCl / 1.) 17.5 h., reflux, ethanol, 2.) water

2: 100 percent / NaNO₂ / ethanol; acetic acid / 1.5 h / Ambient temperature

3: 1.) dimsyl anion, 2.) 10percent aq. HCl / 1.) DMSO, 20-22 deg C, 10 min., 2.) DMSO, water

4: 1.) NaBH₄, 2.) 10percent ethanolic HCl / 1.) room temp., 2 h., 2.) ethanol

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; dimethyl sulfoxide; deprotonated form; sodium nitrite; In ethanol; acetic acid;
DOI:10.1248/cpb.31.70

Reference yield:

: 86495-21-8
(R)-5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 82775-57-3
(+/-)-5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / NaNO₂ / ethanol; acetic acid / 1.5 h / Ambient temperature

2: 1.) dimsyl anion, 2.) 10percent aq. HCl / 1.) DMSO, 20-22 deg C, 10 min., 2.) DMSO, water

3: 1.) NaBH₄, 2.) 10percent ethanolic HCl / 1.) room temp., 2 h., 2.) ethanol

With hydrogenchloride; sodium tetrahydroborate; dimethyl sulfoxide; deprotonated form; sodium nitrite; In ethanol; acetic acid;
DOI:10.1248/cpb.31.70

Reference yield:

: 71605-46-4,67950-89-4
(R)-1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline-5,7-diol

: 82775-57-3
(+/-)-5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Ac₂O, 2.) 30percent aq. K₂CO₃ / 1.) THF, room temp., 2 h., 2.) THF, water, room temp.

2: 86 percent / NaI, K₂CO₃ / dimethylsulfoxide / 1.) room temp. 19.5 h., 2.) 40 deg C, 1 h.

3: 1.) 10percent aq. NaOH, 2.) 10percent ethanolic HCl / 1.) 17.5 h., reflux, ethanol, 2.) water

4: 100 percent / NaNO₂ / ethanol; acetic acid / 1.5 h / Ambient temperature

5: 1.) dimsyl anion, 2.) 10percent aq. HCl / 1.) DMSO, 20-22 deg C, 10 min., 2.) DMSO, water

6: 1.) NaBH₄, 2.) 10percent ethanolic HCl / 1.) room temp., 2 h., 2.) ethanol

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; dimethyl sulfoxide; deprotonated form; acetic anhydride; potassium carbonate; sodium iodide; sodium nitrite; In ethanol; acetic acid; dimethyl sulfoxide;
DOI:10.1248/cpb.31.70