5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-3,4-dihydroisoquinoline hydrochloride

Base Information

Chemical Name:5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-3,4-dihydroisoquinoline hydrochloride
CAS No.:82775-56-2
Molecular Formula:C₃₃H₃₃NO₅*ClH
Molecular Weight:560.09
Hs Code.:

Synonyms:5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-3,4-dihydroisoquinoline hydrochloride

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Chemical Property of 5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-3,4-dihydroisoquinoline hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-3,4-dihydroisoquinoline hydrochloride

There total 6 articles about 5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-3,4-dihydroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82775-54-0
(R)-5,7-dibenzyloxy-N-formyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

: 82775-56-2
5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-3,4-dihydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 10percent aq. NaOH, 2.) 10percent ethanolic HCl / 1.) 17.5 h., reflux, ethanol, 2.) water

2: 100 percent / NaNO₂ / ethanol; acetic acid / 1.5 h / Ambient temperature

3: 1.) dimsyl anion, 2.) 10percent aq. HCl / 1.) DMSO, 20-22 deg C, 10 min., 2.) DMSO, water

With hydrogenchloride; sodium hydroxide; dimethyl sulfoxide; deprotonated form; sodium nitrite; In ethanol; acetic acid;
DOI:10.1248/cpb.31.70

Reference yield:

: 86495-21-8
(R)-5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 82775-56-2
5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-3,4-dihydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / NaNO₂ / ethanol; acetic acid / 1.5 h / Ambient temperature

2: 1.) dimsyl anion, 2.) 10percent aq. HCl / 1.) DMSO, 20-22 deg C, 10 min., 2.) DMSO, water

With hydrogenchloride; dimethyl sulfoxide; deprotonated form; sodium nitrite; In ethanol; acetic acid;
DOI:10.1248/cpb.31.70

Reference yield:

: 71605-46-4,67950-89-4
(R)-1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline-5,7-diol

: 82775-56-2
5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-3,4-dihydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Ac₂O, 2.) 30percent aq. K₂CO₃ / 1.) THF, room temp., 2 h., 2.) THF, water, room temp.

2: 86 percent / NaI, K₂CO₃ / dimethylsulfoxide / 1.) room temp. 19.5 h., 2.) 40 deg C, 1 h.

3: 1.) 10percent aq. NaOH, 2.) 10percent ethanolic HCl / 1.) 17.5 h., reflux, ethanol, 2.) water

4: 100 percent / NaNO₂ / ethanol; acetic acid / 1.5 h / Ambient temperature

5: 1.) dimsyl anion, 2.) 10percent aq. HCl / 1.) DMSO, 20-22 deg C, 10 min., 2.) DMSO, water

With hydrogenchloride; sodium hydroxide; dimethyl sulfoxide; deprotonated form; acetic anhydride; potassium carbonate; sodium iodide; sodium nitrite; In ethanol; acetic acid; dimethyl sulfoxide;
DOI:10.1248/cpb.31.70