Technology Process of 3-[(2,6-difluoro-3-hydroxy-anilino)methyl]-5-(3-fluorophenyl)benzonitrile
There total 10 articles about 3-[(2,6-difluoro-3-hydroxy-anilino)methyl]-5-(3-fluorophenyl)benzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
borane-THF;
In
tetrahydrofuran;
at 0 - 50 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C
2: thionyl chloride / Reflux
3: ammonia / tetrahydrofuran
4: trichlorophosphate / 100 °C
5: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C
6: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 100 °C
7: thionyl chloride / Reflux
8: sodium hydrogencarbonate / tetrahydrofuran / 3 h / 20 °C
9: borane-THF / tetrahydrofuran / 6 h / 0 - 50 °C
With
tetrakis(triphenylphosphine) palladium(0); thionyl chloride; borane-THF; lithium hydroxide monohydrate; ammonia; water; sodium hydrogencarbonate; potassium carbonate; trichlorophosphate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 20 °C
2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C
3.1: thionyl chloride / Reflux
4.1: ammonia / tetrahydrofuran
5.1: trichlorophosphate / 100 °C
6.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C
7.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 100 °C
8.1: thionyl chloride / Reflux
9.1: sodium hydrogencarbonate / tetrahydrofuran / 3 h / 20 °C
10.1: borane-THF / tetrahydrofuran / 6 h / 0 - 50 °C
With
tetrakis(triphenylphosphine) palladium(0); thionyl chloride; borane-THF; lithium hydroxide monohydrate; ammonia; water; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; trichlorophosphate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
