3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyanopyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionic acid

Base Information

Chemical Name:3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyanopyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionic acid
CAS No.:1239708-62-3
Molecular Formula:C₂₂H₂₀N₆O₄S
Molecular Weight:464.505
Hs Code.:

Synonyms:3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyanopyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionic acid

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Chemical Property of 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyanopyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionic acid

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Technology Process of 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyanopyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionic acid

There total 8 articles about 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyanopyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239708-61-2
Methyl 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyano-pyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionate

: 1239708-62-3
3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyanopyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionic acid

Guidance literature:: Methyl 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyano-pyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionate; With lithium hydroxide monohydrate; water; In acetonitrile; at 80 ℃; for 2h;

With citric acid; In acetonitrile; at 50 ℃; for 1h;

Reference yield:

: 33674-96-3
2-bromo-6-(hydroxymethyl)pyridine

: 1239708-62-3
3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyanopyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrabutyl-ammonium chloride; sodium hydrogencarbonate / palladium diacetate / N,N-dimethyl-formamide / 5 h / 80 °C / Molecular sieve; Inert atmosphere

2.1: hydrogen / 5%-palladium/activated carbon / isopropyl alcohol / 2.5 h / 50 °C / 760.05 Torr

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h

4.1: triethylamine / dichloromethane / 0.17 h / Cooling with ice

4.2: 0.5 h / Cooling with ice

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

6.1: water; lithium hydroxide monohydrate / acetonitrile / 2 h / 80 °C

6.2: 1 h / 50 °C

With lithium hydroxide monohydrate; tetrabutyl-ammonium chloride; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; 5%-palladium/activated carbon; palladium diacetate; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 868769-88-4
methyl 3-(6-hydroxymethylpyridin-2-yl)-trans-acrylate

: 1239708-62-3
3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyanopyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / 5%-palladium/activated carbon / isopropyl alcohol / 2.5 h / 50 °C / 760.05 Torr

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h

3.1: triethylamine / dichloromethane / 0.17 h / Cooling with ice

3.2: 0.5 h / Cooling with ice

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: water; lithium hydroxide monohydrate / acetonitrile / 2 h / 80 °C

5.2: 1 h / 50 °C

With lithium hydroxide monohydrate; water; hydrogen; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; 5%-palladium/activated carbon; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;