Methyl 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyano-pyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionate

Base Information

Chemical Name:Methyl 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyano-pyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionate
CAS No.:1239708-61-2
Molecular Formula:C₂₃H₂₂N₆O₄S
Molecular Weight:478.531
Hs Code.:

Synonyms:Methyl 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyano-pyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionate

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Chemical Property of Methyl 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyano-pyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionate

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Technology Process of Methyl 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyano-pyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionate

There total 7 articles about Methyl 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyano-pyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33674-96-3
2-bromo-6-(hydroxymethyl)pyridine

: 1239708-61-2
Methyl 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyano-pyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutyl-ammonium chloride; sodium hydrogencarbonate / palladium diacetate / N,N-dimethyl-formamide / 5 h / 80 °C / Molecular sieve; Inert atmosphere

2.1: hydrogen / 5%-palladium/activated carbon / isopropyl alcohol / 2.5 h / 50 °C / 760.05 Torr

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h

4.1: triethylamine / dichloromethane / 0.17 h / Cooling with ice

4.2: 0.5 h / Cooling with ice

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; 5%-palladium/activated carbon; palladium diacetate; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 868769-88-4
methyl 3-(6-hydroxymethylpyridin-2-yl)-trans-acrylate

: 1239708-61-2
Methyl 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyano-pyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / 5%-palladium/activated carbon / isopropyl alcohol / 2.5 h / 50 °C / 760.05 Torr

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h

3.1: triethylamine / dichloromethane / 0.17 h / Cooling with ice

3.2: 0.5 h / Cooling with ice

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With hydrogen; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; 5%-palladium/activated carbon; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 26088-79-9
N‐(4‐(2,2‐dicyanovinyl)phenyl)acetamide

: 1239708-61-2
Methyl 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyano-pyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / ethanol / 0.5 h / 60 °C

1.2: 5 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With sodium carbonate; potassium carbonate; In ethanol; N,N-dimethyl-formamide;