Technology Process of Methyl 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyano-pyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionate
There total 7 articles about Methyl 3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyano-pyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: tetrabutyl-ammonium chloride; sodium hydrogencarbonate / palladium diacetate / N,N-dimethyl-formamide / 5 h / 80 °C / Molecular sieve; Inert atmosphere
2.1: hydrogen / 5%-palladium/activated carbon / isopropyl alcohol / 2.5 h / 50 °C / 760.05 Torr
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h
4.1: triethylamine / dichloromethane / 0.17 h / Cooling with ice
4.2: 0.5 h / Cooling with ice
5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
With
tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid;
5%-palladium/activated carbon; palladium diacetate;
In
dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / 5%-palladium/activated carbon / isopropyl alcohol / 2.5 h / 50 °C / 760.05 Torr
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h
3.1: triethylamine / dichloromethane / 0.17 h / Cooling with ice
3.2: 0.5 h / Cooling with ice
4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
With
hydrogen; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid;
5%-palladium/activated carbon;
In
dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium carbonate / ethanol / 0.5 h / 60 °C
1.2: 5 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
With
sodium carbonate; potassium carbonate;
In
ethanol; N,N-dimethyl-formamide;
