t-butyl 4-((4-(3-(6-((4-(4-acetamidophenyl)-6-amino-5-cyanopyrimidin-2-ylthio)methyl)-1-oxy-pyridin-2-yl)propanoyl)piperazin-1-yl)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:t-butyl 4-((4-(3-(6-((4-(4-acetamidophenyl)-6-amino-5-cyanopyrimidin-2-ylthio)methyl)-1-oxy-pyridin-2-yl)propanoyl)piperazin-1-yl)methyl)piperidine-1-carboxylate
CAS No.:1239708-63-4
Molecular Formula:C₃₇H₄₇N₉O₅S
Molecular Weight:729.903
Hs Code.:

t-butyl 4-((4-(3-(6-((4-(4-acetamidophenyl)-6-amino-5-cyanopyrimidin-2-ylthio)methyl)-1-oxy-pyridin-2-yl)propanoyl)piperazin-1-yl)methyl)piperidine-1-carboxylate

Synonyms:t-butyl 4-((4-(3-(6-((4-(4-acetamidophenyl)-6-amino-5-cyanopyrimidin-2-ylthio)methyl)-1-oxy-pyridin-2-yl)propanoyl)piperazin-1-yl)methyl)piperidine-1-carboxylate

Suppliers and Price of t-butyl 4-((4-(3-(6-((4-(4-acetamidophenyl)-6-amino-5-cyanopyrimidin-2-ylthio)methyl)-1-oxy-pyridin-2-yl)propanoyl)piperazin-1-yl)methyl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of t-butyl 4-((4-(3-(6-((4-(4-acetamidophenyl)-6-amino-5-cyanopyrimidin-2-ylthio)methyl)-1-oxy-pyridin-2-yl)propanoyl)piperazin-1-yl)methyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of t-butyl 4-((4-(3-(6-((4-(4-acetamidophenyl)-6-amino-5-cyanopyrimidin-2-ylthio)methyl)-1-oxy-pyridin-2-yl)propanoyl)piperazin-1-yl)methyl)piperidine-1-carboxylate

There total 12 articles about t-butyl 4-((4-(3-(6-((4-(4-acetamidophenyl)-6-amino-5-cyanopyrimidin-2-ylthio)methyl)-1-oxy-pyridin-2-yl)propanoyl)piperazin-1-yl)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 381722-48-1
tert-butyl 4-(piperazin-1-ylmethyl)piperidine-1-carboxylate

: 1239708-62-3
3-{6-[4-(4-acetylaminophenyl)-6-amino-5-cyanopyrimidin-2-ylsulfanylmethyl]-1-oxy-pyridin-2-yl}propionic acid

: 1239708-63-4
t-butyl 4-((4-(3-(6-((4-(4-acetamidophenyl)-6-amino-5-cyanopyrimidin-2-ylthio)methyl)-1-oxy-pyridin-2-yl)propanoyl)piperazin-1-yl)methyl)piperidine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; acetone; for 2h; Reflux;

Reference yield:

: 33674-96-3
2-bromo-6-(hydroxymethyl)pyridine

: 1239708-63-4
t-butyl 4-((4-(3-(6-((4-(4-acetamidophenyl)-6-amino-5-cyanopyrimidin-2-ylthio)methyl)-1-oxy-pyridin-2-yl)propanoyl)piperazin-1-yl)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrabutyl-ammonium chloride; sodium hydrogencarbonate / palladium diacetate / N,N-dimethyl-formamide / 5 h / 80 °C / Molecular sieve; Inert atmosphere

2.1: hydrogen / 5%-palladium/activated carbon / isopropyl alcohol / 2.5 h / 50 °C / 760.05 Torr

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h

4.1: triethylamine / dichloromethane / 0.17 h / Cooling with ice

4.2: 0.5 h / Cooling with ice

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

6.1: water; lithium hydroxide monohydrate / acetonitrile / 2 h / 80 °C

6.2: 1 h / 50 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; acetone / 2 h / Reflux

With lithium hydroxide monohydrate; tetrabutyl-ammonium chloride; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; 5%-palladium/activated carbon; palladium diacetate; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone; acetonitrile;

Reference yield:

: 868769-88-4
methyl 3-(6-hydroxymethylpyridin-2-yl)-trans-acrylate

: 1239708-63-4
t-butyl 4-((4-(3-(6-((4-(4-acetamidophenyl)-6-amino-5-cyanopyrimidin-2-ylthio)methyl)-1-oxy-pyridin-2-yl)propanoyl)piperazin-1-yl)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / 5%-palladium/activated carbon / isopropyl alcohol / 2.5 h / 50 °C / 760.05 Torr

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h

3.1: triethylamine / dichloromethane / 0.17 h / Cooling with ice

3.2: 0.5 h / Cooling with ice

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: water; lithium hydroxide monohydrate / acetonitrile / 2 h / 80 °C

5.2: 1 h / 50 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; acetone / 2 h / Reflux

With lithium hydroxide monohydrate; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; 5%-palladium/activated carbon; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone; acetonitrile;