ethyl 5-[(5-ethoxycarbonyl-3-methyl-4-phenyl-1H-pyrrol-2-yl)phenylmethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: ethyl 5-[(5-ethoxycarbonyl-3-methyl-4-phenyl-1H-pyrrol-2-yl)phenylmethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylate
• CAS No.: 367254-81-7
• Molecular Formula: C₃₅H₃₄N₂O₄
• Molecular Weight: 546.666

Synonyms:ethyl 5-[(5-ethoxycarbonyl-3-methyl-4-phenyl-1H-pyrrol-2-yl)phenylmethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylate

Chemical Property of ethyl 5-[(5-ethoxycarbonyl-3-methyl-4-phenyl-1H-pyrrol-2-yl)phenylmethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylate

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Technology Process of ethyl 5-[(5-ethoxycarbonyl-3-methyl-4-phenyl-1H-pyrrol-2-yl)phenylmethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylate

There total 6 articles about ethyl 5-[(5-ethoxycarbonyl-3-methyl-4-phenyl-1H-pyrrol-2-yl)phenylmethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzaldehyde (100-52-7) + ethyl 4-methyl-3-phenyl-1H-pyrrole-2-carboxylate (124901-12-8) → ethyl 5-[(5-ethoxycarbonyl-3-methyl-4-phenyl-1H-pyrrol-2-yl)phenylmethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylate (367254-81-7)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2018.07.054

Reference yield:

1-phenyl-2-nitroprop-1-ene (705-60-2,18315-84-9,58321-79-2) → ethyl 5-[(5-ethoxycarbonyl-3-methyl-4-phenyl-1H-pyrrol-2-yl)phenylmethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylate (367254-81-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / DBU / tetrahydrofuran; propan-2-ol / 3 h / 20 °C

2: 71 percent / methanesulfonic acid / CH₂Cl₂ / 24 h

With methanesulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; isopropyl alcohol;

DOI:10.1134/S1070428007020236

Reference yield:

Ethyl isocyanoacetate (2999-46-4) → ethyl 5-[(5-ethoxycarbonyl-3-methyl-4-phenyl-1H-pyrrol-2-yl)phenylmethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylate (367254-81-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / DBU / tetrahydrofuran; propan-2-ol / 3 h / 20 °C

2: 71 percent / methanesulfonic acid / CH₂Cl₂ / 24 h

With methanesulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; isopropyl alcohol;

DOI:10.1134/S1070428007020236

upstream raw materials:

benzaldehyde

ethyl 4-methyl-3-phenyl-1H-pyrrole-2-carboxylate

1-phenyl-2-nitroprop-1-ene

Ethyl isocyanoacetate

Downstream raw materials:

C₄₃H₃₈N₆O₂

5-[(5-carboxy-3-methyl-4-phenyl-1H-pyrrol-2-yl)phenylmethyl]-4-methyl-3-phenyl-1H-pyrrole-2-carboxylic acid

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