3-<<4-(1,1-dimethylethyl)benzyl>amino>benzyl (1,1-dimethylethyl)dimethylsilyl ether

Base Information

• Chemical Name: 3-<<4-(1,1-dimethylethyl)benzyl>amino>benzyl (1,1-dimethylethyl)dimethylsilyl ether
• CAS No.: 174355-84-1
• Molecular Formula: C₂₄H₃₇NOSi
• Molecular Weight: 383.649

Synonyms:3-<<4-(1,1-dimethylethyl)benzyl>amino>benzyl (1,1-dimethylethyl)dimethylsilyl ether

Chemical Property of 3-<<4-(1,1-dimethylethyl)benzyl>amino>benzyl (1,1-dimethylethyl)dimethylsilyl ether

Chemical Property:

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Technology Process of 3-<<4-(1,1-dimethylethyl)benzyl>amino>benzyl (1,1-dimethylethyl)dimethylsilyl ether

There total 3 articles about 3-<<4-(1,1-dimethylethyl)benzyl>amino>benzyl (1,1-dimethylethyl)dimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1-(bromomethyl)-4-(1,1-dimethylethyl)benzene (18880-00-7) + 3-[[tert-butyl(dimethyl)silyl]-oxymethyl]aniline (159217-95-5) → 3-<<4-(1,1-dimethylethyl)benzyl>amino>benzyl (1,1-dimethylethyl)dimethylsilyl ether (174355-84-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 4h; Heating;

DOI:10.1021/jo951098g

Reference yield:

3-aminobenzenemethanol (1877-77-6) → 3-<<4-(1,1-dimethylethyl)benzyl>amino>benzyl (1,1-dimethylethyl)dimethylsilyl ether (174355-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / imidazole / dimethylformamide / 10 h / Ambient temperature

2: 50 percent / Et₃N / tetrahydrofuran / 4 h / Heating

With 1H-imidazole; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jo951098g

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 3-<<4-(1,1-dimethylethyl)benzyl>amino>benzyl (1,1-dimethylethyl)dimethylsilyl ether (174355-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / imidazole / dimethylformamide / 10 h / Ambient temperature

2: 50 percent / Et₃N / tetrahydrofuran / 4 h / Heating

With 1H-imidazole; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jo951098g

upstream raw materials:

1-(bromomethyl)-4-(1,1-dimethylethyl)benzene

3-[[tert-butyl(dimethyl)silyl]-oxymethyl]aniline

3-aminobenzenemethanol

tert-butyldimethylsilyl chloride

Downstream raw materials:

5-Bromo-N-(4-tert-butyl-benzyl)-N-[3-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzamide

2-[4-Amino-6-(3,3-dimethyl-butylamino)-[1,3,5]triazin-2-ylamino]-5-bromo-N-(4-tert-butyl-benzyl)-N-[3-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-benzamide

2-(4-Amino-6-chloro-[1,3,5]triazin-2-ylamino)-5-bromo-N-(4-tert-butyl-benzyl)-N-[3-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-benzamide

2-[4-Amino-6-(3,3-dimethyl-butylamino)-[1,3,5]triazin-2-ylamino]-5-bromo-N-(4-tert-butyl-benzyl)-N-(3-hydroxymethyl-phenyl)-benzamide

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