(R)-N-(1-(4-(trifluoromethyl)phenyl)propyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:(R)-N-(1-(4-(trifluoromethyl)phenyl)propyl)-4-methylbenzenesulfonamide
CAS No.:1323722-87-7
Molecular Formula:C₁₇H₁₈F₃NO₂S
Molecular Weight:357.397
Hs Code.:

Synonyms:(R)-N-(1-(4-(trifluoromethyl)phenyl)propyl)-4-methylbenzenesulfonamide

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Chemical Property of (R)-N-(1-(4-(trifluoromethyl)phenyl)propyl)-4-methylbenzenesulfonamide

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Technology Process of (R)-N-(1-(4-(trifluoromethyl)phenyl)propyl)-4-methylbenzenesulfonamide

There total 3 articles about (R)-N-(1-(4-(trifluoromethyl)phenyl)propyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 163926-77-0
4-methyl-N-[propylidene]benzene-1-sulfonamide

: 1323722-87-7
(R)-N-(1-(4-(trifluoromethyl)phenyl)propyl)-4-methylbenzenesulfonamide

Guidance literature:: With C₄₀H₃₈O₂Rh₂; In 1,4-dioxane; at 70 ℃; for 6h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1021/ja2046217

Reference yield: 93.0%

: 557-20-0
diethylzinc

: 198012-02-1
4-methyl-N-(4-trifluoromethylbenzylidene)-benzenesulfonamide

: 1323722-87-7
(R)-N-(1-(4-(trifluoromethyl)phenyl)propyl)-4-methylbenzenesulfonamide

Guidance literature:: diethylzinc; With (S)-1-(3-methyl-2-pivalamidobutyl)-3-(pyridin-2-yl)-1H-imidazol-3-ium chloride; copper(II) bis(trifluoromethanesulfonate); In N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; toluene; at 0 ℃; for 0.55h; Inert atmosphere;

4-methyl-N-(4-trifluoromethylbenzylidene)-benzenesulfonamide; In N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; toluene; at 0 ℃; for 24h; enantioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201404241

Reference yield:

: 70-55-3
toluene-4-sulfonamide

: 1323722-87-7
(R)-N-(1-(4-(trifluoromethyl)phenyl)propyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid; sodium 4-methylbenzenesulfinate / water / 20 °C / Inert atmosphere

2: C₄₀H₃₈O₂Rh₂ / 1,4-dioxane / 6 h / 70 °C / Inert atmosphere; Molecular sieve

With formic acid; C₄₀H₃₈O₂Rh₂; sodium 4-methylbenzenesulfinate; In 1,4-dioxane; water;
DOI:10.1021/ja2046217