3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-2H-isoquinolin-1-one

Base Information

Chemical Name:3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-2H-isoquinolin-1-one
CAS No.:1256488-49-9
Molecular Formula:C₂₅H₂₄N₂O₃
Molecular Weight:400.477
Hs Code.:

Synonyms:3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-2H-isoquinolin-1-one

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Chemical Property of 3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-2H-isoquinolin-1-one

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Technology Process of 3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-2H-isoquinolin-1-one

There total 9 articles about 3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-2H-isoquinolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1256489-02-7
C₃₂H₃₀N₂O₃

: 1256488-49-9
3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-2H-isoquinolin-1-one

Guidance literature:: C₃₂H₃₀N₂O₃; With hydrogen bromide; In acetic acid; at 20 ℃;

With sodium hydrogencarbonate; In water; acetic acid;

Reference yield:

: 52200-49-4
3-bromo-2-(phenylmethoxy)pyridine

: 1256488-49-9
3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: potassium acetate; bis(pinacol)diborane / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 26 h / 70 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; dichloromethane / 0.5 h / 115 °C / Sealed tube; Microwave Irradiation

3: sodium methylate / methanol / -78 - 20 °C

4: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 75 °C

5: hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II) / ethanol / 85 °C

6: hydrogen bromide / acetic acid / 20 °C

With copper(l) iodide; hydrogen bromide; sodium methylate; potassium acetate; sodium carbonate; triethylamine; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 24623-65-2
3-tert-butyl-2-hydroxybenzaldehyde

: 1256488-49-9
3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 7 steps

1: bromine / dichloromethane / 1.5 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; dichloromethane / 0.5 h / 115 °C / Sealed tube; Microwave Irradiation

4: sodium methylate / methanol / -78 - 20 °C

5: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 75 °C

6: hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II) / ethanol / 85 °C

7: hydrogen bromide / acetic acid / 20 °C

With copper(l) iodide; hydrogen bromide; bromine; sodium methylate; sodium carbonate; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); In methanol; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;