2-BENZYLOXYPYRIDIN-3-YLBORONIC ACID

Base Information

• Chemical Name: 2-BENZYLOXYPYRIDIN-3-YLBORONIC ACID
• CAS No.: 1072952-41-0
• Molecular Formula: C12H12BNO3
• Molecular Weight: 229.043
• Hs Code.: 2933399990
• Mol file: 1072952-41-0.mol

Synonyms:2-Benzyloxypyridin-3-ylboronic acid;(2-Benzyloxy-3-pyridyl)boronic acid;2-(Benzyloxy)pyridine-3-boronic acid;

Chemical Property of 2-BENZYLOXYPYRIDIN-3-YLBORONIC ACID

Chemical Property:

• Vapor Pressure: 2.78E-08mmHg at 25°C
• Melting Point: 145-147 °C
• Refractive Index: 1.596
• Boiling Point: 433.4 °C at 760 mmHg
• PKA: 6.93±0.53(Predicted)
• Flash Point: 215.9 °C
• PSA: 62.58000
• Density: 1.25 g/cm³
• LogP: 0.34040
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Benzyloxypyridine-3-boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BENZYLOXYPYRIDIN-3-YLBORONIC ACID

There total 3 articles about 2-BENZYLOXYPYRIDIN-3-YLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-2-(phenylmethoxy)pyridine (52200-49-4) → (2-benzyloxy-3-pyridyl)boronic acid (1072952-41-0)

Guidance literature:

3-bromo-2-(phenylmethoxy)pyridine; With potassium acetate; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; at 70 ℃; for 26h; under 760.051 Torr; Inert atmosphere;

With water; In 1,2-dimethoxyethane; ethyl acetate; Cooling;

Reference yield:

3-bromo-2-(phenylmethoxy)pyridine (52200-49-4) + Pd(II)Cl2(PPh3)2 + bis(pinacol)diborane (73183-34-3) → (2-benzyloxy-3-pyridyl)boronic acid (1072952-41-0)

Guidance literature:

With potassium acetate; In 1,2-dimethoxyethane;

Reference yield:

3-bromo-2-(phenylmethoxy)pyridine (52200-49-4) + Pd(II) Cl2(PPh3)2 + bis(pinacol)diborane (73183-34-3) → (2-benzyloxy-3-pyridyl)boronic acid (1072952-41-0)

Guidance literature:

With potassium acetate; In 1,2-dimethoxyethane; ethyl acetate;

upstream raw materials:

3-bromo-2-(phenylmethoxy)pyridine

bis(pinacol)diborane

Downstream raw materials:

N-(4-{2-[3-tert-butyl-6-hydroxy-2-methoxy-5-(2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-ethyl}-phenyl)-methanesulfonamide

methyl 2-[2-[5-(2-benzyloxy-3-pyridyl)-3-tert-butyl-2-methoxyphenyl]ethynyl]-5-[bis(methylsulfonyl)amino]benzoate

C₃₃H₃₆N₂O₇S

C₃₃H₃₄N₂O₇S