Technology Process of 2-cyclopropyl-6-methyl-4-morpholin-4-yl-benzoic acid ethyl ester
There total 9 articles about 2-cyclopropyl-6-methyl-4-morpholin-4-yl-benzoic acid ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium fluoride; tetrakis(triphenylphosphine) palladium(0); potassium bromide;
In
toluene;
at 120 ℃;
for 1.33333h;
Inert atmosphere;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C
1.2: 4 h / 0 - 50 °C
2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 18 h / -78 - 23 °C
2.2: 1 h / 0 - 23 °C
3.1: sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.5 h / 23 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 23 °C
5.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16.5 h / 120 °C / Inert atmosphere
6.1: boron tribromide / dichloromethane / 1.5 h / -78 - 23 °C
6.2: Cooling
7.1: caesium carbonate / dichloromethane; acetonitrile / 2 h / 23 °C
8.1: potassium fluoride; potassium bromide; tetrakis(triphenylphosphine) palladium(0) / toluene / 1.33 h / 120 °C / Inert atmosphere; Microwave irradiation
With
hydrogenchloride; potassium fluoride; sodium chlorite; tris-(dibenzylideneacetone)dipalladium(0); sodium dihydrogenphosphate; tetrakis(triphenylphosphine) palladium(0); 2-methyl-but-2-ene; boron tribromide; diisobutylaluminium hydride; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium bromide; sodium nitrite;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 18 h / -78 - 23 °C
1.2: 1 h / 0 - 23 °C
2.1: sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.5 h / 23 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 23 °C
4.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16.5 h / 120 °C / Inert atmosphere
5.1: boron tribromide / dichloromethane / 1.5 h / -78 - 23 °C
5.2: Cooling
6.1: caesium carbonate / dichloromethane; acetonitrile / 2 h / 23 °C
7.1: potassium fluoride; potassium bromide; tetrakis(triphenylphosphine) palladium(0) / toluene / 1.33 h / 120 °C / Inert atmosphere; Microwave irradiation
With
potassium fluoride; sodium chlorite; tris-(dibenzylideneacetone)dipalladium(0); sodium dihydrogenphosphate; tetrakis(triphenylphosphine) palladium(0); 2-methyl-but-2-ene; boron tribromide; diisobutylaluminium hydride; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium bromide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;
