Formic acid 2-[(S)-6-(toluene-4-sulfonyl)-spiro[4.5]dec-6-en-(2E)-ylidene]-propyl ester

Base Information

Chemical Name:Formic acid 2-[(S)-6-(toluene-4-sulfonyl)-spiro[4.5]dec-6-en-(2E)-ylidene]-propyl ester
CAS No.:186357-57-3
Molecular Formula:C₂₁H₂₆O₄S
Molecular Weight:374.501
Hs Code.:

Synonyms:Formic acid 2-[(S)-6-(toluene-4-sulfonyl)-spiro[4.5]dec-6-en-(2E)-ylidene]-propyl ester

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Chemical Property of Formic acid 2-[(S)-6-(toluene-4-sulfonyl)-spiro[4.5]dec-6-en-(2E)-ylidene]-propyl ester

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Technology Process of Formic acid 2-[(S)-6-(toluene-4-sulfonyl)-spiro[4.5]dec-6-en-(2E)-ylidene]-propyl ester

There total 6 articles about Formic acid 2-[(S)-6-(toluene-4-sulfonyl)-spiro[4.5]dec-6-en-(2E)-ylidene]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 64-18-6
formic acid

: 180524-22-5
2-[(S)-6-(Toluene-4-sulfonyl)-spiro[4.5]dec-6-en-(2E)-ylidene]-propan-1-ol

: 186357-57-3
Formic acid 2-[(S)-6-(toluene-4-sulfonyl)-spiro[4.5]dec-6-en-(2E)-ylidene]-propyl ester

Guidance literature:: With pyridine; acetic anhydride;
DOI:10.1039/CC9960001655

Reference yield:

: 180524-19-0
3-<(1S,6R)-6-(p-tolylthio)bicyclo<4.1.0>heptan-1-yl>propanal

: 186357-57-3
Formic acid 2-[(S)-6-(toluene-4-sulfonyl)-spiro[4.5]dec-6-en-(2E)-ylidene]-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / toluene / Heating

3: 97 percent / MCPBA / CH₂Cl₂ / 0 °C

4: 85 percent / DIBAL-H / CH₂Cl₂ / -78 °C

5: 87 percent / Ac₂O, pyridine

With pyridine; acetic anhydride; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene;
DOI:10.1039/CC9960001655

Reference yield:

: 155501-29-4
3-<(1S,6R)-6-(p-tolylthio)bicyclo<4.1.0>hept-1-yl>propanol

: 186357-57-3
Formic acid 2-[(S)-6-(toluene-4-sulfonyl)-spiro[4.5]dec-6-en-(2E)-ylidene]-propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -50 deg C

2: 90 percent / toluene / Heating

4: 97 percent / MCPBA / CH₂Cl₂ / 0 °C

5: 85 percent / DIBAL-H / CH₂Cl₂ / -78 °C

6: 87 percent / Ac₂O, pyridine

With pyridine; oxalyl dichloride; acetic anhydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene;
DOI:10.1039/CC9960001655