(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxylylcyclohexane

Base Information

• Chemical Name: (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxylylcyclohexane
• CAS No.: 1605280-80-5
• Molecular Formula: C₂₅H₃₈O₄
• Molecular Weight: 402.574
• Mol file: 1605280-80-5.mol

Synonyms:(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxylylcyclohexane

Chemical Property of (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxylylcyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxylylcyclohexane

There total 2 articles about (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxylylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-bis(tert-butyldimethylsilyloxy)phenyl]-4-isopropenyl-1-carboxylcyclohexane (1605281-26-2) → (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxylylcyclohexane (1605280-80-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield:

(1R,3R,4R)-3-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-4-isopropenyl-cyclohexanecarbaldehyde (213915-75-4) → (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxylylcyclohexane (1605280-80-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium dihydrogenphosphate / tert-butyl alcohol; water / 0.17 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

With sodium dihydrogenphosphate; tetrabutyl ammonium fluoride; In tetrahydrofuran; water; tert-butyl alcohol;

Reference yield: 71.0%

(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxylylcyclohexane (1605280-80-5) + diazomethyl-trimethyl-silane (18107-18-1) → (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-methoxycarbonylcyclohexane (1605280-83-8) + (1R,3R,4R)-methyl 3-(2-hydroxy-6-methoxy-4-(2-methyloctan-2-yl)phenyl)-4-(prop-1-en-2-yl)cyclohexanecarboxylate (1605280-84-9)

Guidance literature:

In methanol; toluene; at 0 - 20 ℃;

upstream raw materials:

(1R,3R,4R)-3-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-4-isopropenyl-cyclohexanecarbaldehyde

(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-bis(tert-butyldimethylsilyloxy)phenyl]-4-isopropenyl-1-carboxylcyclohexane

Downstream raw materials:

(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-methoxycarbonylcyclohexane

(1R,3R,4R)-methyl 3-(2-hydroxy-6-methoxy-4-(2-methyloctan-2-yl)phenyl)-4-(prop-1-en-2-yl)cyclohexanecarboxylate