(1R,3R,4R)-methyl 3-(2-hydroxy-6-methoxy-4-(2-methyloctan-2-yl)phenyl)-4-(prop-1-en-2-yl)cyclohexanecarboxylate

Base Information

• Chemical Name: (1R,3R,4R)-methyl 3-(2-hydroxy-6-methoxy-4-(2-methyloctan-2-yl)phenyl)-4-(prop-1-en-2-yl)cyclohexanecarboxylate
• CAS No.: 1605280-84-9
• Molecular Formula: C₂₇H₄₂O₄
• Molecular Weight: 430.628
• Mol file: 1605280-84-9.mol

Synonyms:(1R,3R,4R)-methyl 3-(2-hydroxy-6-methoxy-4-(2-methyloctan-2-yl)phenyl)-4-(prop-1-en-2-yl)cyclohexanecarboxylate

Chemical Property of (1R,3R,4R)-methyl 3-(2-hydroxy-6-methoxy-4-(2-methyloctan-2-yl)phenyl)-4-(prop-1-en-2-yl)cyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3R,4R)-methyl 3-(2-hydroxy-6-methoxy-4-(2-methyloctan-2-yl)phenyl)-4-(prop-1-en-2-yl)cyclohexanecarboxylate

There total 3 articles about (1R,3R,4R)-methyl 3-(2-hydroxy-6-methoxy-4-(2-methyloctan-2-yl)phenyl)-4-(prop-1-en-2-yl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxylylcyclohexane (1605280-80-5) + diazomethyl-trimethyl-silane (18107-18-1) → (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-methoxycarbonylcyclohexane (1605280-83-8) + (1R,3R,4R)-methyl 3-(2-hydroxy-6-methoxy-4-(2-methyloctan-2-yl)phenyl)-4-(prop-1-en-2-yl)cyclohexanecarboxylate (1605280-84-9)

Guidance literature:

In methanol; toluene; at 0 - 20 ℃;

Reference yield:

(1R,3R,4R)-3-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-4-isopropenyl-cyclohexanecarbaldehyde (213915-75-4) → (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-methoxycarbonylcyclohexane (1605280-83-8) + (1R,3R,4R)-methyl 3-(2-hydroxy-6-methoxy-4-(2-methyloctan-2-yl)phenyl)-4-(prop-1-en-2-yl)cyclohexanecarboxylate (1605280-84-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium dihydrogenphosphate / tert-butyl alcohol; water / 0.17 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

3: toluene; methanol / 0 - 20 °C

With sodium dihydrogenphosphate; tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; water; toluene; tert-butyl alcohol;

Reference yield:

(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-bis(tert-butyldimethylsilyloxy)phenyl]-4-isopropenyl-1-carboxylcyclohexane (1605281-26-2) → (1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-methoxycarbonylcyclohexane (1605280-83-8) + (1R,3R,4R)-methyl 3-(2-hydroxy-6-methoxy-4-(2-methyloctan-2-yl)phenyl)-4-(prop-1-en-2-yl)cyclohexanecarboxylate (1605280-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

2: toluene; methanol / 0 - 20 °C

With tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; toluene;

upstream raw materials:

(1R,3R,4R)-3-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-(1,1-dimethyl-heptyl)-phenyl]-4-isopropenyl-cyclohexanecarbaldehyde

(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-bis(tert-butyldimethylsilyloxy)phenyl]-4-isopropenyl-1-carboxylcyclohexane

(1R,3R,4R)-3-[4-(1',1'-dimethylheptyl)-2,6-dihydroxyphenyl]-4-isopropenyl-1-carboxylylcyclohexane

diazomethyl-trimethyl-silane