2-[2-(2-chloroacetamido)thiazol-4-yl]-3-(4-chlorophenyl)-5-methoxybenzo[b]furan

Base Information

• Chemical Name: 2-[2-(2-chloroacetamido)thiazol-4-yl]-3-(4-chlorophenyl)-5-methoxybenzo[b]furan
• CAS No.: 1052726-63-2
• Molecular Formula: C₂₀H₁₄Cl₂N₂O₃S
• Molecular Weight: 433.315

Synonyms:2-[2-(2-chloroacetamido)thiazol-4-yl]-3-(4-chlorophenyl)-5-methoxybenzo[b]furan

Chemical Property of 2-[2-(2-chloroacetamido)thiazol-4-yl]-3-(4-chlorophenyl)-5-methoxybenzo[b]furan

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Technology Process of 2-[2-(2-chloroacetamido)thiazol-4-yl]-3-(4-chlorophenyl)-5-methoxybenzo[b]furan

There total 1 articles about 2-[2-(2-chloroacetamido)thiazol-4-yl]-3-(4-chlorophenyl)-5-methoxybenzo[b]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-[3-(4-chlorophenyl)-5-methoxybenzofuran-2-yl]thiazol-2-ylamine (803686-08-0) + chloroacetyl chloride (79-04-9) → 2-[2-(2-chloroacetamido)thiazol-4-yl]-3-(4-chlorophenyl)-5-methoxybenzo[b]furan (1052726-63-2)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 8h;

DOI:10.1039/b803313g

Reference yield: 72.0%

morpholine (110-91-8,99108-56-2) + 2-[2-(2-chloroacetamido)thiazol-4-yl]-3-(4-chlorophenyl)-5-methoxybenzo[b]furan (1052726-63-2) → 3-(4-chlorophenyl)-5-methoxy-2-[2-[2-(morpholin-4-yl)acetamido]thiazol-4-yl]benzo[b]furan (1052726-65-4)

Guidance literature:

In acetonitrile; for 3h; Reflux;

DOI:10.1039/b803313g

Reference yield: 38.0%

1-(2-hydroxyethyl)piperazine (103-76-4) + 2-[2-(2-chloroacetamido)thiazol-4-yl]-3-(4-chlorophenyl)-5-methoxybenzo[b]furan (1052726-63-2) → 3-(4-chlorophenyl)-2-[2-[2-[4-(2-hydroxyethyl)piperazin-1-yl]acetamido]thiazol-4-yl]-5-methoxybenzo[b]furan (1052726-67-6)

Guidance literature:

In acetonitrile; at 20 ℃;

DOI:10.1039/b803313g

upstream raw materials:

4-[3-(4-chlorophenyl)-5-methoxybenzofuran-2-yl]thiazol-2-ylamine

chloroacetyl chloride

Downstream raw materials:

3-(4-chlorophenyl)-5-methoxy-2-[2-[2-(morpholin-4-yl)acetamido]thiazol-4-yl]benzo[b]furan

3-(4-chlorophenyl)-2-[2-[2-[4-(2-hydroxyethyl)piperazin-1-yl]acetamido]thiazol-4-yl]-5-methoxybenzo[b]furan

2-(2-amino-5-formylthiazol-4-yl)-3-(4-chlorophenyl)-5-methoxybenzo[b]furan

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