N⁴-Benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)cytidin

Base Information

• Chemical Name: N⁴-Benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)cytidin
• CAS No.: 72409-32-6
• Molecular Formula: C₄₈H₆₁N₃O₇Si₂
• Molecular Weight: 848.199
• Mol file: 72409-32-6.mol

Synonyms:N⁴-Benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)cytidin

Chemical Property of N⁴-Benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)cytidin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-Benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)cytidin

There total 6 articles about N⁴-Benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)cytidin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

tert-butyldimethylsilyl chloride (18162-48-6) + N4-benzoyl-5'-O-(4-monomethoxytrityl)cytidine (72409-15-5) → N4-benzoyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(4-monomethoxytrityl)cytidine (72409-31-5) + N4-Benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)cytidin (72409-32-6) + N4-benzoyl-2'-O-(tert-butyldimethylsilyl)-5'-O-(4-monomethoxytrityl)cytidine (72409-30-4)

Guidance literature:

With 1H-imidazole; In dimethyl sulfoxide; N,N-dimethyl-formamide; 1) 0 deg C, 1 h, 2) 24 h, room temperature;

Reference yield:

benzoic acid anhydride (93-97-0) → N4-Benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)cytidin (72409-32-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / methanol / 12 h / Heating

2: 98 percent / pyridine; dimethylsulfoxide / 24 h / Ambient temperature

3: 11 percent / imidazol / dimethylformamide; dimethylsulfoxide / 1) 0 deg C, 1 h, 2) 24 h, room temperature

With 1H-imidazole; In pyridine; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

N4-benzoylcytidine (13089-48-0) → N4-Benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)cytidin (72409-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / pyridine; dimethylsulfoxide / 24 h / Ambient temperature

2: 11 percent / imidazol / dimethylformamide; dimethylsulfoxide / 1) 0 deg C, 1 h, 2) 24 h, room temperature

With 1H-imidazole; In pyridine; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyldimethylsilyl chloride

N⁴-benzoyl-5'-O-(4-monomethoxytrityl)cytidine

benzoic acid anhydride

N₄-benzoylcytidine

Downstream raw materials:

N⁴-benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)cytidine