3,5-dichloro-N-((4'-chloro-2-methoxybiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

Base Information

Chemical Name:3,5-dichloro-N-((4'-chloro-2-methoxybiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide
CAS No.:1201662-79-4
Molecular Formula:C₂₇H₂₁Cl₃FNO₄S
Molecular Weight:580.891
Hs Code.:

Synonyms:3,5-dichloro-N-((4'-chloro-2-methoxybiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

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Chemical Property of 3,5-dichloro-N-((4'-chloro-2-methoxybiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

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Technology Process of 3,5-dichloro-N-((4'-chloro-2-methoxybiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

There total 5 articles about 3,5-dichloro-N-((4'-chloro-2-methoxybiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1201663-92-4
1-(4'-chloro-2-methoxybiphenyl-3-yl)-N-(4-fluorobenzyl)methanamine

: 23378-88-3
3,5-dichloro-2-hydroxybenzenesulfonyl chloride

: 1201662-79-4
3,5-dichloro-N-((4'-chloro-2-methoxybiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

Guidance literature:: 1-(4'-chloro-2-methoxybiphenyl-3-yl)-N-(4-fluorobenzyl)methanamine; With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

3,5-dichloro-2-hydroxybenzenesulfonyl chloride; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 101084-39-3
2-methoxy-3-bromobenzoic acid

: 1201662-79-4
3,5-dichloro-N-((4'-chloro-2-methoxybiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine; oxalyl dichloride / dichloromethane / 20 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 12 h / 120 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.2: 0.5 h / 0 °C

4.1: pyridinium chlorochromate / dichloromethane / 1 h / 0 °C

5.1: methanol / 2 h / Reflux

5.2: 0.5 h / 0 °C

5.3: 1 h / 20 °C

6.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

6.2: 12 h / 20 °C

With pyridine; lithium aluminium tetrahydride; oxalyl dichloride; potassium carbonate; triethylamine; pyridinium chlorochromate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 260806-90-4
methyl 3-bromo-2-methoxybenzoate

: 1201662-79-4
3,5-dichloro-N-((4'-chloro-2-methoxybiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 12 h / 120 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 0 °C

3.1: pyridinium chlorochromate / dichloromethane / 1 h / 0 °C

4.1: methanol / 2 h / Reflux

4.2: 0.5 h / 0 °C

4.3: 1 h / 20 °C

5.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

5.2: 12 h / 20 °C

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; pyridinium chlorochromate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; toluene;