methyl 3-bromo-2-methoxybenzoate

Base Information

• Chemical Name: methyl 3-bromo-2-methoxybenzoate
• CAS No.: 260806-90-4
• Molecular Formula: C9H9BrO3
• Molecular Weight: 245.073
• Hs Code.: 2918990090
• Mol file: 260806-90-4.mol

Synonyms:methyl 3-bromo-2-methoxybenzoate

Chemical Property of methyl 3-bromo-2-methoxybenzoate

Chemical Property:

• Vapor Pressure: 0.00221mmHg at 25°C
• Boiling Point: 289.4°C at 760 mmHg
• Flash Point: 128.8°C
• PSA: 35.53000
• Density: 1.462g/cm³
• LogP: 2.24430
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

methyl 3-bromo-2-methoxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-bromo-2-methoxybenzoate

There total 4 articles about methyl 3-bromo-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 2-methoxy-3-bromobenzoic acid (101084-39-3) → methyl 3-bromo-2-methoxybenzoate (260806-90-4)

Guidance literature:

With sulfuric acid; for 24h; Reflux;

DOI:10.1016/j.ejmech.2015.11.012

Reference yield: 97.0%

3-bromosalicylic acid (3883-95-2) + methyl iodide (74-88-4) → methyl 3-bromo-2-methoxybenzoate (260806-90-4)

Guidance literature:

With potassium carbonate; In acetone; for 16h; Reflux;

Reference yield: 92.0%

2-methoxy-3-bromobenzoic acid (101084-39-3) → methyl 3-bromo-2-methoxybenzoate (260806-90-4)

Guidance literature:

With sulfuric acid; In methanol; Reflux;

upstream raw materials:

3-bromosalicylic acid

dimethyl sulfate

methanol

2-methoxy-3-bromobenzoic acid

Downstream raw materials:

2-methoxy-3-octyl-benzoic acid methyl ester

3,5-dichloro-N-((4'-chloro-2-methoxybiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

1-(4'-chloro-2-methoxybiphenyl-3-yl)-N-(4-fluorobenzyl)methanamine

Refernces

• 1、 -. "MODIFIED PROTEINS AND PROTEIN DEGRADERS". Paragraph 00639-00641. . Retrieved 2021/12/08.
• 2、 Bertini, Simone,Parkkari, Teija,Savinainen, Juha R.,Arena, Chiara,Saccomanni, Giuseppe,Saguto, Simone,Ligresti, Alessia,Allarà, Marco,Bruno, Agostino,Marinelli, Luciana,Di Marzo, Vincenzo,Novellino, Ettore,Manera, Clementina,Macchia, Marco. "Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands". . p. 526 - 536. Retrieved 2015/02/19.