methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-methoxypicolinate

Base Information

Chemical Name:methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-methoxypicolinate
CAS No.:1417331-20-4
Molecular Formula:C₁₅H₁₄ClFN₂O₄
Molecular Weight:340.739
Hs Code.:

Synonyms:methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-methoxypicolinate

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Chemical Property of methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-methoxypicolinate

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Technology Process of methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-methoxypicolinate

There total 5 articles about methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-methoxypicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1417331-18-0
methyl 4-acetamido-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-methoxypicolinate

: 75-36-5
acetyl chloride

: 1417331-20-4
methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-methoxypicolinate

Guidance literature:: In methanol; at 25 ℃;

Reference yield:

: 851442-71-2
4-acetylamino-3-benzyloxy-6-bromo-pyridine-2-carboxylic acid methyl ester

: 1417331-20-4
methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-methoxypicolinate

Guidance literature:: Multi-step reaction with 4 steps

1: cesium fluoride / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.25 h / 100 °C / microwave irradiation

2: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 24 h

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 24 h

4: methanol / 25 °C

With hydrogen; triphenylphosphine; cesium fluoride; diethylazodicarboxylate; bis-triphenylphosphine-palladium(II) chloride; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water;

Reference yield:

: 1417332-47-8
methyl 4-acetamido-3-(benzyloxy)-6-(4-chloro-2-fluoro-3-methoxyphenyl)picolinate

: 1417331-20-4
methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-methoxypicolinate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 24 h

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 24 h

3: methanol / 25 °C

With hydrogen; triphenylphosphine; diethylazodicarboxylate; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; ethanol;