2-hydroxy-3,3-diphenylbutyronitrile

Base Information

Chemical Name:2-hydroxy-3,3-diphenylbutyronitrile
CAS No.:197971-84-9
Molecular Formula:C₁₆H₁₅NO
Molecular Weight:237.301
Hs Code.:

Synonyms:2-hydroxy-3,3-diphenylbutyronitrile

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Chemical Property of 2-hydroxy-3,3-diphenylbutyronitrile

Chemical Property:

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Technology Process of 2-hydroxy-3,3-diphenylbutyronitrile

There total 7 articles about 2-hydroxy-3,3-diphenylbutyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: potassium cyanide

: 22875-82-7
2,2-diphenylpropanal

: 197971-84-9
2-hydroxy-3,3-diphenylbutyronitrile

Guidance literature:: In tetrahydrofuran; water; at 40 ℃; for 3h;

Reference yield:

: 773837-37-9
sodium cyanide

: 5558-67-8
2,2-diphenylpropionitrile

: 197971-84-9
2-hydroxy-3,3-diphenylbutyronitrile

Guidance literature:: 2,2-diphenylpropionitrile; With diisobutylaluminium hydride; In toluene; Large scale;

sodium cyanide; With methanesulfonic acid; Large scale;
DOI:10.1021/op000040n

Reference yield:

: 5558-66-7
2,2-diphenylpropanoic acid

: 197971-84-9
2-hydroxy-3,3-diphenylbutyronitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / SOCl₂, DMF / 1 h / Ambient temperature

2: 75 percent / LiAlH₄ / diethyl ether / 1.) 48 h, 2.) reflux, 2 h

3: 98 percent / PCC / CH₂Cl₂ / 4 h

4: 1.) aq. NaHSO₃, 2.) aq. Me₂NH / 1.) 15 min, 2.) 20 min; 24 h

With lithium aluminium tetrahydride; thionyl chloride; sodium hydrogensulfite; dimethyl amine; N,N-dimethyl-formamide; pyridinium chlorochromate; In diethyl ether; dichloromethane;
DOI:10.1002/jlac.199719970122