(S)-2-(4,6-dimethylpyrimid-2-yloxy)-3,3-diphenylbutyricacid

Base Information

Chemical Name:(S)-2-(4,6-dimethylpyrimid-2-yloxy)-3,3-diphenylbutyricacid
CAS No.:318472-14-9
Molecular Formula:C₂₂H₂₂N₂O₃
Molecular Weight:362.428
Hs Code.:

Synonyms:(S)-2-(4,6-dimethylpyrimid-2-yloxy)-3,3-diphenylbutyricacid

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Chemical Property of (S)-2-(4,6-dimethylpyrimid-2-yloxy)-3,3-diphenylbutyricacid

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Technology Process of (S)-2-(4,6-dimethylpyrimid-2-yloxy)-3,3-diphenylbutyricacid

There total 8 articles about (S)-2-(4,6-dimethylpyrimid-2-yloxy)-3,3-diphenylbutyricacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: (S,S)-[1-(4-chlorophenyl)ethylammonium]-2-hydroxy-3,3-diphenylbutyrate

: 35144-22-0
4,6-dimethyl-2-methylsulfonylpyrimidine

: 318472-14-9
(S)-2-(4,6-dimethylpyrimid-2-yloxy)-3,3-diphenylbutyricacid

Guidance literature:: (S,S)-[1-(4-chlorophenyl)ethylammonium]-2-hydroxy-3,3-diphenylbutyrate; 4,6-dimethyl-2-methylsulfonylpyrimidine; With lithium amide; In N,N-dimethyl-formamide; toluene; at 45 ℃; for 12h; Large scale;

With hydrogenchloride; In water; N,N-dimethyl-formamide; toluene; Solvent; Large scale;
DOI:10.1021/op000040n

Reference yield:

: 2-(4,6-Dimethyl-2-pyrimidinyloxy)-3,3-diphenylbutyric Acid

: (R)-2-(4,6-dimethyl-2-pyrimidinyloxy)-3,3-diphenylbutyric acid

: 318472-14-9
(S)-2-(4,6-dimethylpyrimid-2-yloxy)-3,3-diphenylbutyricacid

Guidance literature:: Resolution of racemate;

Reference yield:

: 5558-67-8
2,2-diphenylpropionitrile

: 318472-14-9
(S)-2-(4,6-dimethylpyrimid-2-yloxy)-3,3-diphenylbutyricacid

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / toluene / Large scale

1.2: Large scale

2.1: sulfuric acid; acetic acid / water / Large scale

3.1: isopropyl alcohol / 7 h / 0 - 80 °C / Large scale

4.1: lithium amide / N,N-dimethyl-formamide; toluene / 12 h / 45 °C / Large scale

4.2: Large scale

With lithium amide; sulfuric acid; diisobutylaluminium hydride; acetic acid; In water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1021/op000040n