Technology Process of 2-hydroxy-3,3-diphenylbutyric acid
There total 6 articles about 2-hydroxy-3,3-diphenylbutyric acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl 2-hydroxy-3,3-diphenylbutyrate;
With
lithium hydroxide;
In
tetrahydrofuran; water;
at 20 - 40 ℃;
for 20h;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diisobutylaluminium hydride / toluene / Large scale
1.2: Large scale
2.1: sulfuric acid; acetic acid / water / Large scale
With
sulfuric acid; diisobutylaluminium hydride; acetic acid;
In
water; toluene;
DOI:10.1021/op000040n
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium methylate / tetrahydrofuran / 4 h / 0 °C / Large scale
2.1: toluene; n-heptane / -10 - -5 °C / Large scale
2.2: Large scale
3.1: potassium hydroxide / isopropyl alcohol / 1 h / Reflux; Large scale
3.2: Large scale
With
sodium methylate; potassium hydroxide;
In
tetrahydrofuran; n-heptane; isopropyl alcohol; toluene;
1.1: |Darzens Condensation;
DOI:10.1021/op000040n
