3-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)propionic acid dipropylcarbamoylmethyl ester succinate salt

Base Information

Chemical Name:3-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)propionic acid dipropylcarbamoylmethyl ester succinate salt
CAS No.:1458672-32-6
Molecular Formula:C₄H₆O₄*C₃₀H₄₁ClN₁₀O₇S
Molecular Weight:839.327
Hs Code.:

3-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)propionic acid dipropylcarbamoylmethyl ester succinate salt

Synonyms:3-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)propionic acid dipropylcarbamoylmethyl ester succinate salt

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Chemical Property of 3-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)propionic acid dipropylcarbamoylmethyl ester succinate salt

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Technology Process of 3-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)propionic acid dipropylcarbamoylmethyl ester succinate salt

There total 9 articles about 3-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)propionic acid dipropylcarbamoylmethyl ester succinate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-15-6
succinic acid

: 1366295-61-5
3-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)propionic acid dipropylcarbamoylmethyl ester

: 1458672-32-6
3-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)propionic acid dipropylcarbamoylmethyl ester succinate salt

Guidance literature:: In water; acetonitrile; at 20 - 50 ℃; for 16.5h; Concentration; Solvent; Temperature; Time;

Reference yield:

: 2315-37-9
2-chloro-N,N-dipropylacetamide

: 1458672-32-6
3-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)propionic acid dipropylcarbamoylmethyl ester succinate salt

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

3: dmap; triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; water / 24 h / 20 °C

5: water; acetonitrile / 16.5 h / 20 - 50 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1366067-80-2
3-benzyloxycarbonylaminopropionic acid dipropylcarbamoylmethyl ester

: 1458672-32-6
3-(3-{2-[(E)-3,5-diamino-6-chloropyrazine-2-carbonylimino]-1,3,8-triazaspiro[4.5]decane-8-carbonyl}benzenesulfonylamino)propionic acid dipropylcarbamoylmethyl ester succinate salt

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / Isopropyl acetate / 3.5 h / 20 °C / 2280.15 Torr

2: dmap; 4-methyl-morpholine / water; Isopropyl acetate / 2 h / 0 - 5 °C

3: palladium 10% on activated carbon; hydrogen / Isopropyl acetate / 760.05 - 2280.15 Torr

4: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; water / 24 h / 20 °C

5: water; acetonitrile / 16.5 h / 20 - 50 °C

With 4-methyl-morpholine; dmap; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; Isopropyl acetate; water; acetonitrile;