methyl 2-(2-((2-(methylthio)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

Base Information

Chemical Name:methyl 2-(2-((2-(methylthio)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate
CAS No.:1393653-51-4
Molecular Formula:C₁₇H₁₃F₃N₂O₂S
Molecular Weight:366.364
Hs Code.:

Synonyms:methyl 2-(2-((2-(methylthio)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

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Chemical Property of methyl 2-(2-((2-(methylthio)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

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Technology Process of methyl 2-(2-((2-(methylthio)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

There total 5 articles about methyl 2-(2-((2-(methylthio)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1393653-50-3
4-iodo-2-(methylthio)-5-(trifluoromethyl)pyrimidine

: 637348-19-7
(2-ethynylphenyl)acetic acid methyl ester

: 1393653-51-4
methyl 2-(2-((2-(methylthio)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; In dichloromethane; at 100 ℃; for 0.166667h; Inert atmosphere; microwave irradiation;

Reference yield:

: 66370-75-0
methyl (2-iodophenyl)acetate

: 1393653-51-4
methyl 2-(2-((2-(methylthio)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / dichloromethane; tetrahydrofuran / 1 h / 0 - 20 °C

3: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.17 h / 100 °C / Inert atmosphere; microwave irradiation

With tetrabutyl ammonium fluoride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 18698-96-9
o-iodophenylacetic acid

: 1393653-51-4
methyl 2-(2-((2-(methylthio)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 16 h / 80 °C / Inert atmosphere

2: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / dichloromethane; tetrahydrofuran / 1 h / 0 - 20 °C

4: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.17 h / 100 °C / Inert atmosphere; microwave irradiation

With sulfuric acid; tetrabutyl ammonium fluoride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; dichloromethane;