637348-19-7

Usage

Uses

Used in Organic Synthesis:
Methyl 2-(2-ethynylphenyl)acetate is used as a building block in organic synthesis for the production of various pharmaceuticals and fine chemicals. Its unique chemical structure allows for the creation of a wide range of compounds with diverse applications.
Used in Pharmaceutical Industry:
Methyl 2-(2-ethynylphenyl)acetate is used as a key intermediate in the synthesis of pharmaceuticals. Its unique structure contributes to the development of new drugs with potential therapeutic benefits.
Used in Flavoring Agent:
In the food and beverage industry, Methyl 2-(2-ethynylphenyl)acetate is used as a flavoring agent. Its distinct chemical properties allow it to impart unique flavors and aromas to various food products and beverages.
Used in Chemical Research:
Due to its unique chemical structure and properties, Methyl 2-(2-ethynylphenyl)acetate is also used in chemical research for studying various chemical reactions and mechanisms. This helps in advancing the understanding of organic chemistry and the development of new synthetic methods.

InChI:InChI=1/C11H10O2/c1-3-9-6-4-5-7-10(9)8-11(12)13-2/h1,4-7H,8H2,2H3

Upstream product

• 59473-45-9 2-(chloromethyl)iodobenzene 
• 66370-75-0 methyl (2-iodophenyl)acetate 
• 1066-54-2 trimethylsilylacetylene 
• 1160367-50-9 methyl 2-(2-(3-hydroxy-3-methylbut-1-ynyl)phenyl)acetate 
• 103-82-2 phenylacetic acid 
• 40400-15-5 2-(2-iodophenyl)acetonitrile 
• 799804-49-2 (2-trimethylsilanylethynyl-phenyl)-acetic acid methyl ester 

Downstream Products

• 637348-24-4 [2-(2-amino-phenylethynyl)-phenyl]-acetic acid methyl ester 
• 1011458-25-5 methyl 2-diazo-2-(2-ethynylphenyl)acetate 
• 1393900-91-8 tert-butyl 3-(4-((4-((2-(2-methoxy-2-oxoethyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393653-51-4 methyl 2-(2-((2-(methylthio)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate 
• 1393901-77-3 tert-butyl 3-(4-((4-((2-(2-methoxy-2-oxoethyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxylate 
• 1393900-80-5 tert-butyl 4-(4-((4-((2-(2-methoxy-2-oxoethyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate 
• 1393901-47-7 tert-butyl 4-(4-((4-((2-(2-methoxy-2-oxoethyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate 
• 1393901-36-4 methyl 2-(2-((2-((4-(4-((tert-butoxycarbonyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate 
• 1393901-04-6 tert-butyl 4-(4-((4-((2-(2-methoxy-2-oxoethyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393900-43-0 2-(2-(2-(2-((4-(1-methylpiperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide 
• 1393900-42-9 2-(2-(2-(2-((4-(piperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide 
• 1393900-94-1 tert-butyl 3-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393900-93-0 lithium 2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate 
• 1393900-92-9 tert-butyl 3-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 

Relevant academic research and scientific papers

Gold-catalyzed intermolecular [4+1] spiroannulation: via site-selective aromatic C(sp2)-H functionalization and dearomatization of phenol derivatives

Herein, we have developed a novel and simple protocol to realize the C-H bond functionalization/dearomatization of naphthols and phenols with ortho-alkynylaryl-α-diazoesters under gold(i) catalysis. In this protocol, various spirocyclic molecules could be obtained in good yields with excellent chemo- and regio-selectivity and moderate to good diastereoselectivity. This journal is

VEGFR3 INHIBITORS

This invention relates to compounds of the formula (I). The invention also relates to processes for the preparation of the compound of the formula (I), pharmaceutical agents or compositions containing the compound or a method of using the compound for the treatment of proliferative diseases, such as cancer as well as the treatment of diseases ameliorated by the control and/or inhibition of lymphanglogenesis.

FAK AND FLT3 INHIBITORS

The use of a compound of the formula (I): (Formula (I)) in the preparation of a medicament for treating Acute Myeloid Leukemia or a disease ameliorated by the inhibition of Flt3, or Flt3 and FAK.

FAK INHIBITORS

A compound of the formula (I): where R1 or R2 is a cycle amine group and R5 is an aromatic group with a carbonyl containing substituent for use as a FAK inhibitor.

Expedient drug synthesis and diversification via ortho-C-H iodination using recyclable PdI2 as the precatalyst

(Figure Presented) Pd(II)-catalyzed ortho-C-H iodination reactions of phenylacetic acid substrates have been achieved using recyclable PdI2 as the precatalyst. This class of substrates is incompatible with the classic amide formation/ortho-lithiation/iodination sequence. The power of this new technology is demonstrated by facile drug functionalization and drastically shortened syntheses of the drugs diclofenac and lumiracoxib.

6-exo versus 7-endo iodolactonizations of 2-(alkynyl)phenylacetic acids

Exposure of 2-alkynylphenylacetic acids to excess iodine in acetonitrile containing anhydrous potassium carbonate delivers good yields, either of the corresponding isochroman-3-ones or benzo[d]oxepin-2(1H)-ones, depending upon the alkyne substituent: when

Sequential copper(I)-catalyzed reaction of amines with o-acetylenyl- substituted phenyldiazoacetates

A highly efficient, tetrakis(acetonitrile)-copper(I) hexafluorophosphate [Cu(MeCN)4PF6]-catalyzed tandem Cu(I)-carbene N-H insertion/Cu(I)-catalyzed hydroamination of alkynes, which leads to sequential formation of two C-N bonds to yield isoindole derivatives, has been developed.

Cycloisomerization of γ- and δ-acetylenic acids catalyzed by gold(I) chloride

We have developed a gold(I)-catalyzed intramolecular cyclization of γ- and δ-alkyne acids in mild conditions yielding various alkylidene lactones. Whereas a slight electronic effect of the R group was observed on the regioselectivity, bulky substituents o

Ramoplanin derivatives possessing antibacterial activity

Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

Photochemical preparation of highly functionalized 1-indanones

A series of o-alkylphenyl alkyl ketones 1 were synthesized by different methods. The presence of a leaving group X adjacent to the carbonyl group is the special peculiarity of these ketones. Upon irradiation the keto carbonyl group of these compounds undergoes an n-π* excitation followed by a 1,5-hydrogen migration from the o-alkyl substituent to the carbonyl oxygen atom. The thus formed 1,4-diradicals are subject to a very rapid elimination of acid HX, giving 1,5-diradicals. We called this process spin center shift. After intersystem crossing these diradicals cyclize to 1-indanones 20 in good yields. Depending on the solvent and on substituents, o-alkoxyalkyl ketones 22 or benzo-[c]furanes 21 are obtained as byproducts. The mechanism of the cyclization was elucidated by quantum chemical calculations and kinetic measurements.