637348-19-7

Basic information

• Product Name: Methyl2-(2-ethynylphenyl)acetate
• Synonyms: Methyl2-(2-ethynylphenyl)acetate;2-Ethynylbenzeneacetic acid methyl ester;Benzeneacetic acid,2-ethynyl-,methyl ester
• CAS NO: 637348-19-7
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174.198
• Mol File: 637348-19-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 259 °C at 760 mmHg
• Flash Point: 101.9 °C
• Appearance: /
• Density: 1.08 g/cm³
• Vapor Pressure: 0.0133mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: Methyl2-(2-ethynylphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl2-(2-ethynylphenyl)acetate(637348-19-7)
• EPA Substance Registry System: Methyl2-(2-ethynylphenyl)acetate(637348-19-7)

Safety Data

• Hazardous Substances Data: 637348-19-7(Hazardous Substances Data)

Usage

General Description

Methyl 2-(2-ethynylphenyl)acetate is a chemical compound with the molecular formula C11H10O2. It is an ester with a methyl group attached to the oxygen atom of the carbonyl group. The compound contains a phenyl ring with an ethynyl group attached to it. Methyl 2-(2-ethynylphenyl)acetate is commonly used in organic synthesis and as a building block in the production of various pharmaceuticals and fine chemicals. It is also used as a flavoring agent in the food and beverage industry. The compound has a variety of potential applications due to its unique chemical structure and properties.

InChI:InChI=1/C11H10O2/c1-3-9-6-4-5-7-10(9)8-11(12)13-2/h1,4-7H,8H2,2H3

Upstream product

• 103-82-2 phenylacetic acid 
• 1160367-50-9 methyl 2-(2-(3-hydroxy-3-methylbut-1-ynyl)phenyl)acetate 
• 66370-75-0 methyl (2-iodophenyl)acetate 
• 1066-54-2 trimethylsilylacetylene 
• 59473-45-9 2-(chloromethyl)iodobenzene 
• 40400-15-5 2-(2-iodophenyl)acetonitrile 
• 799804-49-2 (2-trimethylsilanylethynyl-phenyl)-acetic acid methyl ester 

Downstream Products

• 1011458-25-5 methyl 2-diazo-2-(2-ethynylphenyl)acetate 
• 1566584-80-2 methyl 2-(2-((2-(4-(1-(tert-butoxycarbonylamino)ethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate 
• 1566584-65-3 tert-butyl 4-(5-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate 
• 1566584-62-0 tert-butyl 4-(4-((4-((2-(2-methoxy-2-oxoethyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-methylphenyl)piperidine-1-carboxylate 
• 1393900-91-8 tert-butyl 3-(4-((4-((2-(2-methoxy-2-oxoethyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393653-51-4 methyl 2-(2-((2-(methylthio)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate 
• 1393901-77-3 tert-butyl 3-(4-((4-((2-(2-methoxy-2-oxoethyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxylate 
• 1393900-80-5 tert-butyl 4-(4-((4-((2-(2-methoxy-2-oxoethyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate 
• 1393901-47-7 tert-butyl 4-(4-((4-((2-(2-methoxy-2-oxoethyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate 
• 1393901-36-4 methyl 2-(2-((2-((4-(4-((tert-butoxycarbonyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate 
• 1393901-04-6 tert-butyl 4-(4-((4-((2-(2-methoxy-2-oxoethyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393900-43-0 2-(2-(2-(2-((4-(1-methylpiperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide 
• 1393900-42-9 2-(2-(2-(2-((4-(piperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide 
• 1393900-94-1 tert-butyl 3-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 

Relevant articles and documents

Gold-catalyzed intermolecular [4+1] spiroannulation: via site-selective aromatic C(sp2)-H functionalization and dearomatization of phenol derivatives

Herein, we have developed a novel and simple protocol to realize the C-H bond functionalization/dearomatization of naphthols and phenols with ortho-alkynylaryl-α-diazoesters under gold(i) catalysis. In this protocol, various spirocyclic molecules could be obtained in good yields with excellent chemo- and regio-selectivity and moderate to good diastereoselectivity. This journal is

FAK AND FLT3 INHIBITORS

The use of a compound of the formula (I): (Formula (I)) in the preparation of a medicament for treating Acute Myeloid Leukemia or a disease ameliorated by the inhibition of Flt3, or Flt3 and FAK.

Expedient drug synthesis and diversification via ortho-C-H iodination using recyclable PdI2 as the precatalyst

(Figure Presented) Pd(II)-catalyzed ortho-C-H iodination reactions of phenylacetic acid substrates have been achieved using recyclable PdI2 as the precatalyst. This class of substrates is incompatible with the classic amide formation/ortho-lithiation/iodination sequence. The power of this new technology is demonstrated by facile drug functionalization and drastically shortened syntheses of the drugs diclofenac and lumiracoxib.