(S)-2-[(S)-2-(2-Chloro-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyric acid methyl ester

Base Information

Chemical Name:(S)-2-[(S)-2-(2-Chloro-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyric acid methyl ester
CAS No.:606966-88-5
Molecular Formula:C₁₇H₂₃ClN₂O₄
Molecular Weight:354.834
Hs Code.:

Synonyms:(S)-2-[(S)-2-(2-Chloro-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyric acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-[(S)-2-(2-Chloro-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyric acid methyl ester

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Technology Process of (S)-2-[(S)-2-(2-Chloro-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyric acid methyl ester

There total 4 articles about (S)-2-[(S)-2-(2-Chloro-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 4818-08-0
N-Z-L-phenylalanyl-L-valine methylester

: 541-88-8
Chloroacetic anhydride

: 606966-88-5
(S)-2-[(S)-2-(2-Chloro-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyric acid methyl ester

Guidance literature:: N-Z-L-phenylalanyl-L-valine methylester; hydrogenolysis;

Chloroacetic anhydride; With sodium hydrogencarbonate; In acetonitrile; at 20 ℃;
DOI:10.1016/S0040-4039(03)01432-1

Reference yield:

: 80870-38-8
(S)-methyl 2-((S)-2-amino-3-phenylpropanamido)-3-methylbutanoate

: 79-04-9
chloroacetyl chloride

: 606966-88-5
(S)-2-[(S)-2-(2-Chloro-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyric acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h; pH=7;
DOI:10.1016/j.bioorg.2019.103163

Reference yield:

: 2754-02-1
N-(N-(1,1-dimethylethoxycarbonyl)-L-phenylalanyl)-L-valine methyl ester

: 606966-88-5
(S)-2-[(S)-2-(2-Chloro-acetylamino)-3-phenyl-propionylamino]-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 3.5 h / 0 - 20 °C

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C / pH 7

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bioorg.2019.103163