[2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoylamino]acetic acid methyl ester

Base Information

Chemical Name:[2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoylamino]acetic acid methyl ester
CAS No.:1447588-12-6
Molecular Formula:C₂₂H₂₀N₂O₄
Molecular Weight:376.412
Hs Code.:

Synonyms:[2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoylamino]acetic acid methyl ester

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Chemical Property of [2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoylamino]acetic acid methyl ester

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Technology Process of [2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoylamino]acetic acid methyl ester

There total 7 articles about [2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoylamino]acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 71805-34-0
2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoic acid

: 1447588-12-6
[2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoylamino]acetic acid methyl ester

Guidance literature:: 2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; for 0.5h;

glycine ethyl ester hydrochloride; With triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.cclet.2013.04.039

Reference yield:

: 85-44-9
phthalic anhydride

: 1447588-12-6
[2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoylamino]acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: Reflux

2.1: thionyl chloride / dichloromethane / 0.75 h / Reflux

3.1: zinc / toluene / 20 °C

4.1: sodium hydroxide; water / methanol / 1 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 0.5 h

5.2: 20 °C

With thionyl chloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; zinc; In tetrahydrofuran; methanol; dichloromethane; toluene; 3.1: |Friedel-Crafts Acylation;
DOI:10.1016/j.cclet.2013.04.039

Reference yield:

: 100-39-0
benzyl bromide

: 1447588-12-6
[2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoylamino]acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / dimethyl sulfoxide / Inert atmosphere

2.1: zinc / toluene / 20 °C

3.1: sodium hydroxide; water / methanol / 1 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 0.5 h

4.2: 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; sodium hydroxide; zinc; In tetrahydrofuran; methanol; dimethyl sulfoxide; toluene; 2.1: |Friedel-Crafts Acylation;
DOI:10.1016/j.cclet.2013.04.039