4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester
• CAS No.: 1447588-13-7
• Molecular Formula: C₂₂H₁₈N₂O₃
• Molecular Weight: 358.397
• Mol file: 1447588-13-7.mol

Synonyms:4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester

Chemical Property of 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester

There total 10 articles about 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

[2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoylamino]acetic acid methyl ester (1447588-12-6) → 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester (1447588-13-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; for 12h; Reflux;

DOI:10.1016/j.cclet.2013.04.039

Reference yield:

methanol (67-56-1) + 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid → 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester (1447588-13-7)

Guidance literature:

With sulfuric acid; for 20h; Reflux;

DOI:10.3184/174751913X13662146264623

Reference yield:

2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoic acid (71805-34-0) → 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester (1447588-13-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 0.5 h

1.2: 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol; tetrahydrofuran / 12 h / Reflux

With benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol;

DOI:10.1016/j.cclet.2013.04.039

upstream raw materials:

methyl 2-(1-benzyl-1H-pyrrole-2-carbonyl) benzoate

2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoic acid

[2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoylamino]acetic acid methyl ester

phthalic anhydride