71805-34-0

Upstream product

• 2051-97-0 1-benzyl-1H-pyrrole 
• 4376-18-5 Monomethyl phthalate 
• 4397-55-1 phthalic monoacid monomethyl ester chloride 
• 100-39-0 benzyl bromide 
• 85-44-9 phthalic anhydride 
• 71739-67-8 methyl 2-(1-benzyl-1H-pyrrole-2-carbonyl) benzoate 

Downstream Products

• 1447588-13-7 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester 
• 1447588-12-6 [2-(1-benzyl-1H-pyrrole-2-carbonyl)benzoylamino]acetic acid methyl ester 
• 1451002-44-0 4-(1-benzyl-1H-pyrrol-2-yl)-1-oxo-1H-isochromene-3-carboxylic acid 
• 71739-73-6 3-(1-benzyl-pyrrol-2-yl)-3-ethoxy-3H-isobenzofuran-1-one 

Relevant academic research and scientific papers

First total synthesis of isoquinolinone alkaloid marinamide and its methyl ester

The first total synthesis of isoquinolinone alkaloid marinamide 1 and its methyl ester 2 was described. The key steps involved a regioselective Friedel-Crafts reaction of 1-benzyl-1H-pyrrole to form the intermediate 8.

Total synthesis of a novel isoquinolinone alkaloid marinamide and its methyl ester

A naturally occurring isoquinolinone alkaloid marinamide and its methyl ester were synthesised from phthalic anhydride over eight steps in 46% and 52% overall yield. The key intermediate methyl 2-(1-benzyl-1H-pyrrole-2-carbonyl) benzoate was synthesised from the acid chloride of mono methyl phthalate and 1-benzyl-1H-pyrrole catalysed by Zinc oxide under solvent-free conditions at room temperature.