Technology Process of 3-(2,3-dihydroxyphenyl)propylphosphonic acid
There total 5 articles about 3-(2,3-dihydroxyphenyl)propylphosphonic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h
3.1: phosphorus tribromide / diethyl ether / 1.5 h / Reflux; Inert atmosphere
4.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
4.2: 48 h / 20 °C / Inert atmosphere
5.1: boron tribromide / dichloromethane / 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; boron tribromide; phosphorus tribromide; sodium hydride; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2012.09.021
DOI:10.1016/j.bmcl.2012.09.021
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h
2.1: phosphorus tribromide / diethyl ether / 1.5 h / Reflux; Inert atmosphere
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
3.2: 48 h / 20 °C / Inert atmosphere
4.1: boron tribromide / dichloromethane / 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; boron tribromide; phosphorus tribromide; sodium hydride;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2012.09.021
DOI:10.1016/j.bmcl.2012.09.021
