dibenzyl 3-(2,3-dimethoxyphenyl)propylphosphonate

Base Information

Chemical Name:dibenzyl 3-(2,3-dimethoxyphenyl)propylphosphonate
CAS No.:1410218-37-9
Molecular Formula:C₂₅H₂₉O₅P
Molecular Weight:440.476
Hs Code.:

Synonyms:dibenzyl 3-(2,3-dimethoxyphenyl)propylphosphonate

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Chemical Property of dibenzyl 3-(2,3-dimethoxyphenyl)propylphosphonate

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Technology Process of dibenzyl 3-(2,3-dimethoxyphenyl)propylphosphonate

There total 4 articles about dibenzyl 3-(2,3-dimethoxyphenyl)propylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 17176-77-1
Dibenzyl phosphite

: 179338-67-1
1-(3-bromopropyl)-2,3-dimethoxybenzene

: 1410218-37-9
dibenzyl 3-(2,3-dimethoxyphenyl)propylphosphonate

Guidance literature:: Dibenzyl phosphite; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

1-(3-bromopropyl)-2,3-dimethoxybenzene; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.09.021 DOI:10.1016/j.bmcl.2012.09.021

Reference yield:

: 7345-82-6
trans-2,3-dimethoxycinnamic acid

: 1410218-37-9
dibenzyl 3-(2,3-dimethoxyphenyl)propylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h

3.1: phosphorus tribromide / diethyl ether / 1.5 h / Reflux; Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

4.2: 48 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; phosphorus tribromide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/j.bmcl.2012.09.021 DOI:10.1016/j.bmcl.2012.09.021

Reference yield:

: 1137838-36-8
(E)-3-(2,3-dimethoxyphenyl)prop-2-en-1-ol

: 1410218-37-9
dibenzyl 3-(2,3-dimethoxyphenyl)propylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h

2.1: phosphorus tribromide / diethyl ether / 1.5 h / Reflux; Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

3.2: 48 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; phosphorus tribromide; sodium hydride; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/j.bmcl.2012.09.021 DOI:10.1016/j.bmcl.2012.09.021