Technology Process of (3R,4R)-3,4-dibenzyloxy-1,1-dibromo-5-tert-butyldimethylsilyloxypent-1-ene
There total 5 articles about (3R,4R)-3,4-dibenzyloxy-1,1-dibromo-5-tert-butyldimethylsilyloxypent-1-ene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NaH, 2.) tetrabutylammonium iodide, 18-crown-6 / 1) THF, room temperature, 1 h; 2) THF, room temperature, 7 h
2: 88 percent / lithium aluminium hydride / tetrahydrofuran / 3 h / Heating
3: 1.) NaH / 1) THF, room temperature, 1 h; 2) THF, room temperature, 3 h
4: DMSO, oxalyl chloride / CH2Cl2 / 1 h / -78 °C
5: 1.) Ph3P, 2.) Et3N / 1) CH2Cl2, 0 deg C, 15 min; 2) CH2Cl2, 0 deg C, 5 min; 3) CH2Cl2, -78 deg C, 5 min
With
lithium aluminium tetrahydride; oxalyl dichloride; 18-crown-6 ether; tetra-(n-butyl)ammonium iodide; sodium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1039/P19950002849
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaH / 1) THF, room temperature, 1 h; 2) THF, room temperature, 3 h
2: DMSO, oxalyl chloride / CH2Cl2 / 1 h / -78 °C
3: 1.) Ph3P, 2.) Et3N / 1) CH2Cl2, 0 deg C, 15 min; 2) CH2Cl2, 0 deg C, 5 min; 3) CH2Cl2, -78 deg C, 5 min
With
oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine;
In
dichloromethane;
DOI:10.1039/P19950002849
- Guidance literature:
-
Multi-step reaction with 2 steps
1: DMSO, oxalyl chloride / CH2Cl2 / 1 h / -78 °C
2: 1.) Ph3P, 2.) Et3N / 1) CH2Cl2, 0 deg C, 15 min; 2) CH2Cl2, 0 deg C, 5 min; 3) CH2Cl2, -78 deg C, 5 min
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine; triphenylphosphine;
In
dichloromethane;
DOI:10.1039/P19950002849
