2-(5-(4-((4-chlorophenyl)thio)-1-(4-fluorophenyl)-1H-pyrazol-3-yl)pyrazin-2-yl)propan-2-ol

Base Information

• Chemical Name: 2-(5-(4-((4-chlorophenyl)thio)-1-(4-fluorophenyl)-1H-pyrazol-3-yl)pyrazin-2-yl)propan-2-ol
• CAS No.: 1199802-19-1
• Molecular Formula: C₂₂H₁₈ClFN₄OS
• Molecular Weight: 440.929
• Mol file: 1199802-19-1.mol

Synonyms:2-(5-(4-((4-chlorophenyl)thio)-1-(4-fluorophenyl)-1H-pyrazol-3-yl)pyrazin-2-yl)propan-2-ol

Chemical Property of 2-(5-(4-((4-chlorophenyl)thio)-1-(4-fluorophenyl)-1H-pyrazol-3-yl)pyrazin-2-yl)propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5-(4-((4-chlorophenyl)thio)-1-(4-fluorophenyl)-1H-pyrazol-3-yl)pyrazin-2-yl)propan-2-ol

There total 4 articles about 2-(5-(4-((4-chlorophenyl)thio)-1-(4-fluorophenyl)-1H-pyrazol-3-yl)pyrazin-2-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

methyl 5-[4-[(4-chlorophenyl)thio]-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-pyrazinecarboxylate (1199804-68-6) + methylmagnesium bromide (75-16-1) → 2-(5-(4-((4-chlorophenyl)thio)-1-(4-fluorophenyl)-1H-pyrazol-3-yl)pyrazin-2-yl)propan-2-ol (1199802-19-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.333333h;

DOI:10.1021/ml5001239

Reference yield:

methyl 5-[1-(4-fluorophenyl)-4-iodo-1H-pyrazol-3-yl]-2-pyrazinecarboxylate (1199804-96-0) → 2-(5-(4-((4-chlorophenyl)thio)-1-(4-fluorophenyl)-1H-pyrazol-3-yl)pyrazin-2-yl)propan-2-ol (1199802-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 0.25 h / 20 °C

1.2: 0.17 h / 150 °C / Microwave irradiation

2.1: tetrahydrofuran / 20 °C

With sodium hydride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;

Reference yield:

methyl 5-chloropyrazine-2-carboxylate (33332-25-1) → 2-(5-(4-((4-chlorophenyl)thio)-1-(4-fluorophenyl)-1H-pyrazol-3-yl)pyrazin-2-yl)propan-2-ol (1199802-19-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride / tetrahydrofuran / 12 h / 70 °C

2.1: N-iodo-succinimide; trifluoroacetic acid / acetonitrile / 1 h / 20 °C

3.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 0.25 h / 20 °C

3.2: 150 °C

4.1: tetrahydrofuran / 0.33 h / 20 °C

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; acetonitrile;

DOI:10.1021/ml5001239

upstream raw materials:

methyl 5-[4-[(4-chlorophenyl)thio]-1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-pyrazinecarboxylate

methylmagnesium bromide

p-Chlorothiophenol

methyl 5-[1-(4-fluorophenyl)-4-iodo-1H-pyrazol-3-yl]-2-pyrazinecarboxylate